000			03692nam a22002897a 4500
003			OSt
005			20240305192638.0
008			230117b |||||||| |||| 00| 0 eng d
020			_a 9783030683344
020			_a3030683346
040			_cDLC
041			_aEnglish
082			_a616.994
100			_aIago Dillion Lima Cavalcanti _948239
222			_aCommon terms and phrases _bacid activity acute addition allow anticancer antigen antineoplastic agents applications associated binding Biol biological bladder breast cancer cancer cells cancer therapy cancer treatment carcinoma cardiotoxicity cause cell cycle cell lung cancer cellular changes chemotherapy Clin clinical colorectal cancer combined damage delivery diagnosis disease drugs effects et al function gene growth factor human ifosfamide imatinib immune system immunotherapy increase Indication induce inhibitors inhibits leukemia levels liposomes liver lymphoma malignant mechanisms mechanisms of action metastatic molecular monoclonal antibodies mutations nanoparticles nanosystems normal Oncol oncology organs ovarian patients phase present produced prostate cancer protein receptor Reference resistance response role shows signaling solid Source specific staging synthesis Table targeted therapy Ther therapeutic tion tissue toxicity treat treatment of cancer tumor tumor cells tumor markers types vaccines vincristine Wang
245			_aAdvances in Cancer Treatment _b From Systemic Chemotherapy to Targeted Therapy
260			_aUniversidade Federal de Pernambuco Recife Pernambuco Brazil: _bSpringer Nature, _cc2021
300			_a109 pages
520			_aThis work covers the pathophysiology of cancer, exploring the difficulty of optimal treatment due to the complexity and diversity of cancer types. The search for distinctive molecular biology characteristics of tumor cells is especially relevant in the identification of overexpressed receptors and proteins that can be used as a target for cancer treatment. We highlight the main therapeutic modalities, particularly conventional systemic chemotherapy, addressing its mechanisms of action, therapeutic classes and even the toxic effects. We also describe the main tumor markers, their importance in the diagnosis and treatment of cancer, and the specificity of tumor cells. The first chapters serve as an introduction to the central topic of this book, targeted therapy. Key aspects of target therapy, such as classes of drugs, immunotherapy, monoclonal antibodies, checkpoint inhibitors, cancer vaccines and tyrosine kinase inhibitors are presented, and, for each one, the benefits, as well as the adverse effects are reported. Chapter 6 compares conventional systemic chemotherapy and targeted therapy, identifies the risks and benefits and also the eligibility criteria for patient care. The possibility of targeted therapy replacing conventional chemotherapy is discussed while reviewing studies that demonstrate the benefits of combining both types of treatment. Finally, the introduction of pharmaceutical nanotechnology to improve antineoplastic agents is addressed in the last chapter and sets the direction for future research in cancer treatment. This is a valuable resource for many health professionals including physicians, pharmacists, nurses, researchers and students interested in the field of oncology.
600			_xMedical / Pharmacy _927229
600			_xMedical / Oncology / General _926891
600			_xMedical / Internal Medicine _926949
600			_x Medical / Clinical Medicine _926816
600			_xMedical  › Oncology  › General _947458
700			_aJosé Cleberson Santos Soares _948240
942			_cEB _2ddc
999			_c9854 _d9854