000			04022nam a22003017a 4500
003			OSt
005			20240305192631.0
008			230111b |||||||| |||| 00| 0 eng d
020			_a9783319996646
020			_a3319996649
040			_cDLC
041			_aEnglish
100			_aGad Frankel _926356
222			_aCommon terms and phrases _bactin activation adherence adhesin AggR antibiotic resistance antigens Antimicrob Agents Chemother apoptosis bacterial beta-lactamases binding biofilm carbapenemase cause chromosome Clin Microbiol clinical clone coli isolates colistin colonization detection diarrhea disease EAEC strain EHEC EIEC encoded enteroaggregative Escherichia coli Enterobacteriaceae enteropathogenic Escherichia coli enzymes EPEC epithelial cells ESBL Escherichia coli Escherichia coli O104:H4 Escherichia coli O157:H7 Escherichia coli strains ETEC ETT2 ExPEC extraintestinal fimbriae flexneri Frankel G genome global GTPases hemolytic uremic syndrome host cell human induce Infect Immun inflammasome Inhibition interaction intestinal Klebsiella pneumoniae membrane Mol Microbiol molecular mucosal Nataro JP NF-jB NF-kB outbreak strain pathogenesis pathogenic Escherichia coli pathotypes pathway patients plasmid PLoS protease protein receptor regulation rodentium role secretion system sequence type serotype Shiga toxin Shigella signalling small GTPases ST131 isolates studies Stx2 subunit syndrome T3SS effectors target toxin-producing Escherichia coli translocation type III secretion vaccine virulence factors virulence genes vitro vivo Wang Zhang
245			_aEscherichia coli, a Versatile Pathogen
260			_aLondon: _bSpringer, _c2018
300			_a242 pages
490			_vVolume 416 of Current Topics in Microbiology and Immunology
505			_aContents: Enteroaggregative Escherichia coli The Type III Secretion System of Pathogenic Escherichia coli Modulation of Host Cell Processes by T3SS Effectors H4 OutbreakThe Danger Is Still Out There Extraintestinal Pathogenic Escherichia coli Evolution and Emergence of DrugResistant Pathogens Current Trends in Antimicrobial Resistance of Escherichia coli Vaccines Against Escherichia coli
520			_aEscherichia coli is a facultative anaerobic Gamma-proteobacterium, which belongs to the family Enterobacteriaceae. While being an important constituent of the normal gut microbiota, specialized E. coli clones have acquired genetic elements that allow them to compete with the endogenous commensals, colonise normally sterile niches and cause disease. E. coli pathotypes can cause intestinal and extra intestinal infections (e.g. UTI, sepsis) and associate with mammalian cells while being extra- or intra-cellular. In recent years, E. coli infections have become a serious clinical problem, due to the rapid spread of antibiotic resistance. Thus, infections with intestinal E. coli (e.g. E. coli O104) or extraintestinal pathogenic strains (e.g. E. coli ST131) are becoming difficult to treat and are often lethal. Consequently, there is a pressing need to develop alternative control measures, including the identification of new drug targets and development of vaccines that offer lasting protection. This volume focuses on several types of E. coli infections (intestinal and extraintestinal), virulence factors, and E. coli pandemics. It addresses the problem of antibiotic resistance, and a dedicated chapter discusses the need to develop alternative control measures. Given its depth and breadth of coverage, the book will benefit all those interested in the biology, genetics, physiology and pathogenesis of E. coli, and in related vaccine development.
600			_xScience / Life Sciences / Bacteriology _947942
600			_x Medical / Microbiology _927394
600			_xMedical / Infectious Diseases _927009
600			_xMedical / General _926821
600			_xScience  › Life Sciences  › Bacteriology _947837
700			_a Eliora Z Ron _926357
942			_2ddc _cEB
999			_c9669 _d9669