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020			_a3319225812
020			_a9783319225814
040			_cdlc
100			_aAlwin Krämer _938267
245			_aCancer of Unknown Primary
250			_a illustrated
260			_aClinical Cooperation Unit Molecular Hematology/Oncology German Cancer Research Center (DKFZ) and University of Heidelberg Heidelberg Germany _bSpringer _c 2015
300			_a194 pages
505			_aContents: Introduction Epidemiology Risk Factors and Survival in CUP Pointers to Disease Mechanisms Biologic Features of CUP Prognostic Factors and Their Role in the Management of CUP Diagnostic Workup of CUP An Approach to Current Recommendations and Underlying Evidence The Radiologists Approach to CUP Cancer of Unknown Primary The Pathologists Approach Treatment of Disseminated CUP Concepts of Radiotherapy in Cancer of Unknown Primary Favorable Subsets Among Cancers of Unknown Primary Novel Diagnostic and Therapeutic Strategies in the Management of Patients with Cancers of Unknown Primary Site Future Directions
520			_aThis book presents an up-to-date and thorough overview of cancer of unknown primary, encompassing topics ranging from epidemiology, tumor biology, and prognostic factors through to the most recent diagnostic and therapeutic advances. All aspects of management are covered, including radiological, nuclear medicine, and pathological diagnosis, site-specific therapies, platinum-based combination chemotherapy, radiotherapy, and novel targeted treatments. Clear guidance is offered on diagnosis of the tissue of origin by means of gene expression and micro-RNA analyses and its therapeutic implications. Detailed directions are also provided on the identification of subsets of patients with a more favorable prognosis, in whom specific treatment offers the chance of long-term survival or even cure. Readers will find Cancer of Unknown Primary to be an ideal source of practically oriented information that will assist in delivery of the best possible care for patients with this challenging diagnosis. _bCommon terms and phrases: adenocarcinoma analysis biopsy brain metastases breast cancer cancer classifier assays cancer of unknown cancer types carcinoma of unknown cervical CUP cervical lymph nodes chemotherapy cisplatin Clin Oncol clinical colorectal cancer CUP patients detection diagnostic disease evaluation favorable subset gemcitabine gene expression profiling genetic germ cell tumors Greco guidelines Hainsworth JD head and neck Hemminki histological identified IHC staining imaging immunohistochemical immunohistochemistry lesion Löffler lung cancer lymph node metastases lymphoma malignant markers median survival melanoma molecular cancer classifier molecular profiling months mutations neuroendocrine tumors nodal occult primary Oncology Pathol pathological patients with carcinoma patients with CUP Pavlidis Pentheroudakis performance status peritoneal poorly differentiated carcinoma primary cancer primary sites primary tumor prognostic factors Pubmed Central PubMed Epub PubMed PMID Radiat Oncol Biol radiotherapy renal cell carcinoma site-specific therapy specific Spigel DR squamous cell carcinoma subgroups targeted therapeutic tissue of origin treatment trials ultrasound unknown primary
600			_xMedical / Pathology _927023
600			_xMedical / Oncology / General _926891
600			_xMedical / Diagnostic Imaging / General _926867
600			_xMedical / Clinical Medicine _926816
600			_xMedical / Allied Health Services / Imaging Technologies _926763
600			_xMedical › Oncology › General _926780
700			_a Harald Löffler _938268
942			_2ddc _cEB
999			_c6777 _d6777