000			04466nam a22001577a 4500
008			210622b |||||||| |||| 00| 0 eng d
020			_a978-981-10-8605-2
020			_a978-981-10-8606-9
100			_aTakuya Moriya _915482
245			_aPathology of Female Cancers
260			_aKawasaki Medical School, Kurashiki, Japan _bSpringer Nature Singapore Pte Ltd. _c2018
300			_a211 Pages
520			_aOften, cancers are characterized by their abrupt occurrence. However, most cancers originate earlier and gradually develop in the subclinical stage. Even though this development varies from organ to organ, it may also differ for each patient. Hence, individualizing patients in terms of effective therapy and the early detection of cancer is imperative. Furthermore, the prevention of cancer is essential to avoid its proliferation. Surgical pathologists are expected to provide a definitive diagnosis of cancer and precisely assess the biological behavior of each patient. However, the accurate diagnosis of precancerous lesions and the precise assessment of the possibility and their progression rate into clinically significant cancer will be spectacular, rendering the precancerous stage as entirely curable. Apparently, the pathological diagnosis of all precancerous stages is complicated, as not all stages are morphologically evident. However, we may be able to detect precancerous “lesions.” On the basis of the organs and/or histological types, the concept and term of these lesions vary, including dysplasia (i.e., uterine cervix), atypical hyperplasia (i.e., endometrium), adenoma (i.e., colorectum), intraepithelial neoplasia, or intraepithelial lesion. Occasionally, intraductal (noninvasive) carcinomas may also be included, as these are non-lethal and their distinction from dysplasia is complicated. The primary feature of precancerous lesions is their potential to progress into definite (invasive) cancer in future, even though the possibility and their progression rates vary, leading to the use of the terms “borderline lesions,” “borderline malignancy,” or “atypically proliferating lesions” in some organs (e.g., ovary). Although benign and malignant tumors may possess a middle degree of atypia, their biological behavior (early stage and the possibility of progression) may not be necessarily considered. At times, the same technical term may be used differently; for example, atypical hyperplasia in the breast signifies risk lesions rather than real precursors, and adenomas in various organs are entirely benign that will not progress into adenocarcinoma. Furthermore, several cancers may not have precursors and directly originate from healthy tissues (de novo cancer). This textbook intends to elucidate the current standards and novel knowledge regarding carcinogenesis, molecular features, histopathological _bdiagnosis, and the clinical significance of precancerous and early-stage female cancers such as breast, ovarian, and uterine carcinomas. Apparently, the pathways of cancer development significantly vary among organs, with heterogeneous precursors and early lesions based on the histological type of cancer in the same organ. Recently, several paradigm shifts have been advocated in these areas, for examples, the underlying mechanism of highgrade serous carcinoma of the ovary (and the peritoneum). It may be reckoned that the recognition of the current concept will lead to the most appropriate approach for the diagnosis, treatment, and patient care. As readers of this book may be familiar with the variegated development of these cancers, this book comprises eight chapters, including two chapters focusing on uterine cervical (precursors of squamous cell carcinoma and adenocarcinoma), one on endometrial (heterogeneity of precursors), three on ovarian (two pathways of carcinogenesis and the significance of borderline tumors), and two on mammary (significance of intrinsic subtype and risk assessment for non-cancerous lesions) cancers. All contributors to this book are exceptional Japanese surgical pathologists. Although each chapter in this book puts forth global perspectives, it also presents Japanese perspective in some parts. I hope that this book serves as a useful reference for grasping the advanced knowledge and facilitate the daily practice of pathologists, gynecologists, breast surgeons, and all medical staff members in these fields.
654			_xPathology
942			_2ddc _cEB
999			_c673 _d673