000			02278nam a22002537a 4500
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005			20240305192341.0
008			220219b |||||||| |||| 00| 0 eng d
020			_a4431555315
020			_a9784431555315
040			_cData centre
100			_aMototsugu Oya _931835
245			_aRenal Cell Carcinoma _b Molecular Features and Treatment Updates
250			_a illustrated
260			_aDepartment of Urology Keio University School of Medicine Tokyo, Japan _bSpringer _c2017
300			_a 381 pages
520			_aThis book provides a comprehensive review of diagnosis and treatments of renal cell carcinoma (RCC) for practitioners and researchers with an interest in this disease. A major aim of the book is to present the most important and most recent advances in molecular bases and targeted therapy for this neoplasm. The remarkable resistance to chemotherapy and radiotherapy and the minimum contribution of cancer genes that commonly mutate in other adult epithelial cancers have made RCC highly distinct from other types of solid neoplasms. In the past decade, however, treatment options for RCC have been expanding and moving quickly toward laboratory-based and molecular-targeted therapies. Advances in RCC therapy also have brought novel treatment options to other types of cancer, such as a TKI for hepatocellular carcinoma and gastrointestinal tumors, as well as mTOR inhibitors to progressive neuroendocrine tumors of pancreatic origin and to breast cancer, suggesting that RCC is no longer an "orphan disease" in the field of molecular oncology. Additional topics covered in the book include pharmacokinetics and pharmacodynamics in molecular-targeted agents and the putative mechanism of resistance to anti-angiogenic agents, such as intratumoral heterogeneity or cancer stem cell population. This volume provides the latest and most useful information for all readers who are eagerly devoted to curing renal cell carcinoma.
600			_x Science / Life Sciences / Molecular Biology _927008
600			_xMedical / Research Medical / Urology _931836
600			_xMedical / Oncology / General _926891
600			_x Medical / Clinical Medicine _926816
600			_x Medical › Oncology › General _926780
942			_2ddc _cEB
999			_c5252 _d5252