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008 160909s2016 gw |||| o |||| 0|eng
010 _a 2019769991
020 _a9783319406978
024 7 _a10.1007/978-3-319-40697-8
_2doi
035 _a(DE-He213)978-3-319-40697-8
040 _aDLC
_beng
_epn
_erda
_cDLC
072 7 _aMED033000
_2bisacsh
072 7 _aMJT
_2bicssc
072 7 _aMKC
_2thema
082 0 4 _a618.2
_223
100 1 _aKällén, Bengt,
_eauthor.
_930941
245 1 0 _aDrugs During Pregnancy :
_bMethodological Aspects /
_cby Bengt Källén.
250 _a1st ed. 2016.
264 1 _aCham :
_bSpringer International Publishing :
_bImprint: Springer,
_c2016.
300 _a1 online resource (XI, 111 pages 26 illustrations in color.)
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aIntroduction -- The alert clinician -- Animal experiments and adverse drug reaction reports -- Some epidemiological principles -- Pregnancy outcomes with the exception of congenital malformations -- Congenital malformations -- Identification of maternal use of drugs -- The problem of confounding -- Statistics -- Lumping or splitting? Paternal use of drugs -- Timing of drug use and effects on the embryo or fetus -- Repeated studies and meta-analysis -- Pharmacovigilance -- Information on the risk with drug use during pregnancy -- Concluding remarks.
520 _aThis book addresses methodological aspects of epidemiological studies on maternal drug use in pregnancy. Discussing the existing sources of error and how they can produce incorrect conclusions, it examines various epidemiological techniques and assesses their strengths and weaknesses. These refer both to the identification of outcomes (with special emphasis on congenital malformations) and to the types of exposure (drug use). Further, the book discusses the problem of confounding and how to handle it, and provides a simple introduction to statistics. Special situations, e.g. different types of parental exposure, are examined. Lastly, the book discusses pharmacovigilance and the information problem, concluding with a short list of aspects to consider when one wants to evaluate a published paper in the field. Though the book is primarily intended for pharmacologists, gynecologists and obstetricians, it will benefit all doctors working in perinatal care.
588 _aDescription based on publisher-supplied MARC data.
650 0 _aObstetrics.
_91175
650 0 _aPharmacotherapy.
_96991
650 1 4 _aObstetrics/Perinatology/Midwifery.
_0https://scigraph.springernature.com/ontologies/product-market-codes/H26014
_94103
650 2 4 _aPharmacotherapy.
_0https://scigraph.springernature.com/ontologies/product-market-codes/H69000
_96991
776 0 8 _iPrint version:
_tDrugs during pregnancy : methodological aspects
_z9783319406961
_w(DLC) 2016952092
776 0 8 _iPrinted edition:
_z9783319406961
776 0 8 _iPrinted edition:
_z9783319406985
776 0 8 _iPrinted edition:
_z9783319821580
906 _a0
_bibc
_corigres
_du
_encip
_f20
_gy-gencatlg
942 _2ddc
_cEB
999 _c4793
_d4793