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001			21819790
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006			m |o d |
007			cr |||||||||||
008			171129s2017 ja |||| o |||| 0|eng
010			_a 2019765509
020			_a9784431565260
024	7		_a10.1007/978-4-431-56526-0 _2doi
035			_a(DE-He213)978-4-431-56526-0
040			_aDLC _beng _epn _erda _cDLC
072		7	_aMED072000 _2bisacsh
072		7	_aTDC _2thema
072		7	_aTDCW _2bicssc
082	0	4	_a615.19 _223
245	0	0	_aSkin Permeation and Disposition of Therapeutic and Cosmeceutical Compounds / _cedited by Kenji Sugibayashi.
250			_a1st ed. 2017.
264		1	_aTokyo : _bSpringer Japan : _bImprint: Springer, _c2017.
300			_a1 online resource (X, 428 pages 153 illustrations, 78 illustrations in color.)
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
520			_aThis book reviews skin permeation and disposition of chemical compounds. Skin is utilized as an administration site for transdermal drug delivery systems, topical drug formulations, cosmeceuticals, and cosmetics. Their usefulness is closely related to the permeation and disposition of entrapped active ingredients through and into the skin. Skin permeation, disposition, and metabolism of chemicals are first summarized in the general introduction. Then primary topical formulations are explained in the second part, "Basic Formulations Applied to Skin". The explanation for the active compounds and formulations are of the most important parts required to fabricate these formulations. Skin absorption of chemicals is generally much lower than oral and the other mucosal absorptions, so that skin-penetration enhancement is a key issue to have good formulations topically applied. Part 3 presents "Skin Penetration Enhancement". In addition, Part 4, "Selection of Topically Applied Chemical Candidates", deals with selection methods of topically applied ingredients for transdermal drug delivery systems, topical drug formulations, cosmeceuticals, and cosmetics. Parts 5 and 6, "Safety Assessment of Topically Applied Compounds" and "Experimental Methods of Skin Permeation", respectively, show safety issues and experimental methods for topical formulations. The final part consists of comments on therapeutic and cosmetic formulations by medical doctors and pharmacists. Their comments are especially helpful for pharmaceutical and cosmetic researchers who study dermatopharmacokinetics and topical formulations. This volume is particularly useful for those working in R&D, graduate students, and educators in the area of pharmaceutics, cosmetic sciences, dermatological sciences, pharmacology, toxicology, biopharmacy, pharmacokinetics, physical pharmacy, chemical engineering, and related fields.
588			_aDescription based on publisher-supplied MARC data.
650		0	_aDermatology. _9335
650		0	_aMedicinal chemistry. _928117
650		0	_aPharmaceutical technology. _9336
650	1	4	_aPharmaceutical Sciences/Technology. _0https://scigraph.springernature.com/ontologies/product-market-codes/B21010 _9337
650	2	4	_aDermatology. _0https://scigraph.springernature.com/ontologies/product-market-codes/H1900X _9335
650	2	4	_aMedicinal Chemistry. _0https://scigraph.springernature.com/ontologies/product-market-codes/C28000 _928118
700	1		_aSugibayashi, Kenji, _eeditor. _928119
776	0	8	_iPrint version: _tSkin permeation and disposition of therapeutic and cosmeceutical compounds _z9784431565246 _w(DLC) 2017958883
776	0	8	_iPrinted edition: _z9784431565246
776	0	8	_iPrinted edition: _z9784431565253
776	0	8	_iPrinted edition: _z9784431568124
906			_a0 _bibc _corigres _du _encip _f20 _gy-gencatlg
942			_2ddc _cEB
999			_c3906 _d3906