000 02170nam a22001817a 4500
008 211207b |||||||| |||| 00| 0 eng d
020 _a 9783319996646
020 _a 3319996649
100 _aGad Frankel
_926356
245 _aEscherichia coli, a Versatile Pathogen
260 _aDepartment of Life Sciences Imperial College London London, UK
_b Springer
_c2018
300 _a 242 pages
490 _v Volume 416 of Current Topics in Microbiology and Immunology
520 _aEscherichia coli is a facultative anaerobic Gamma-proteobacterium, which belongs to the family Enterobacteriaceae. While being an important constituent of the normal gut microbiota, specialized E. coli clones have acquired genetic elements that allow them to compete with the endogenous commensals, colonise normally sterile niches and cause disease. E. coli pathotypes can cause intestinal and extra intestinal infections (e.g. UTI, sepsis) and associate with mammalian cells while being extra- or intra-cellular. In recent years, E. coli infections have become a serious clinical problem, due to the rapid spread of antibiotic resistance. Thus, infections with intestinal E. coli (e.g. E. coli O104) or extraintestinal pathogenic strains (e.g. E. coli ST131) are becoming difficult to treat and are often lethal. Consequently, there is a pressing need to develop alternative control measures, including the identification of new drug targets and development of vaccines that offer lasting protection. This volume focuses on several types of E. coli infections (intestinal and extraintestinal), virulence factors, and E. coli pandemics. It addresses the problem of antibiotic resistance, and a dedicated chapter discusses the need to develop alternative control measures. Given its depth and breadth of coverage, the book will benefit all those interested in the biology, genetics, physiology and pathogenesis of E. coli, and in related vaccine development.
654 _x Science › Life Sciences › Bacteriology Medical / General Medical / Infectious Diseases Medical / Microbiology Science / Life Sciences / Bacteriology
700 _aEliora Z Ron
_926357
942 _2ddc
_cEB
999 _c3310
_d3310