000			02325nam a22002177a 4500
008			211124b |||||||| |||| 00| 0 eng d
020			_a9781402090639
020			_a1402090633
100			_aTamas Fulop _925654
245			_aHandbook on Immunosenescence _b basic understanding and clinical applications _cBiomedical and Life Sciences
250			_a illustrated
260			_aDivision of Geriatrics Research Center on Aging University of Sherbrooke Department of Medicine Sherbrooke, QC, Canada _b Springer Science & Business Media _c2009
300			_a1693 pages
490			_aSpringerLink: Springer
520			_a"Immunosenescence" is an imprecise term used to describe deleterious age-associated changes to immune parameters observed in all mammals studied so far. It represents a rapidly progressing science in the aging field, with a vertiginous volume of new data, knowledge and concepts concerning these changes. We are poised to be in a position to translate these accumulated data into the clinical setting via better understanding of the contribution of immunosenescence to age-associated pathologies, and their prevention by appropriate interventions. This authoritative handbook seeks to encompass the current state of our knowledge on the multitude of those changes to immunity related to aging, with contributions from experts in the research and clinical areas. This book therefore considers methods and models for studying immunosenescence; cellular immunosenescence of T cells, B cells, neutrophils, antigen presenting cells, NK, NKT and stem cells; genetics; mechanisms including receptors and signal transduction; mitochondria; proteasome; cytokines; neuro-endocrine-immune networks; inflammation; thymus; clinical relevance in disease states including infections, autoimmunity, cancer, metabolic syndrome, neurodegenerative diseases, frailty and osteoporosis; modulation by nutrition, lipids, vaccination and the question "can interventions to influence immunosenescence be realistically proposed based on our current state of knowledge?"
654			_x Medical › General Medical / General Medical / Geriatrics Medical / Immunology Medical / Research
700			_aClaudio Franceschi _925655
700			_aKatsuiki Hirokawa _925656
700			_a Graham Pawelec _925657
942			_2ddc _cEB
999			_c3019 _d3019