000			03876nam a22003017a 4500
001			20241101201127.0
003			OCOLC
005			20241104145749.0
008			241101b |||||||| |||| 00| 0 eng d
020			_a1-26-425807-0
020			_a978-1-26-425808-6
020			_a 978-1-26-425807-9
020			_a 1-26-425808-9
040			_cddc
041			_aEnglish
100			_q Laurence Brunton
222			_aabsorption ACh acid action activity administration adrenergic receptor adverse effects agents agonist antidepressants antipsychotic aripiprazole associated atropine BBB benzodiazepines binding blockade blood-brain barrier brain Ca2+ channels carbamazepine cardiac catecholamines cells Chapter cholinergic clearance clinical clozapine CNS compounds concentrations CYPs decrease depolarization depression disease disorders dopamine dosage dose drug efficacy endothelial enzymes EPI epilepsy excretion FDA Figure function G protein GABA gene genetic GPCRs hepatic human hypertension increase inhibition inhibitors interactions K+ kinase levels levodopa Li+ ligand liver mechanisms mediated medications membrane metabolism metabolites mg microbiome modulators molecules muscarinic receptors Na+ nerve neurons neurotransmitter nicotinic oral pathways patients peripheral pharmacokinetics Pharmacol pharmacological phenobarbital phenytoin plasma potential presynaptic receptor agonists receptor antagonists reduced release renal response result risk schizophrenia seizures selective serotonin side effects signaling smooth muscle stimulation substrate subtypes subunits synaptic syndrome target therapeutic therapy tion tissues toxicity transporters treatment uptake variants vascular VMAT2 α β
240			_aGoodman and Gilman's The Pharmacological Basis of Therapeutics.
245			_aGoodman and Gilman's The Pharmacological Basis of Therapeutics.
250			_a14th Edition
260			_aNew York | _bMcGraw Hill LLC | _c2023.
300			_a1664 Pages
300			_aIncludes Index
520			_aA Doody's Core Title for 2023! The landmark pharmacology reference—updated to reflect the latest research and developments in the field For more than 50 years, Goodman & Gilman’s: The Pharmacological Basis of Therapeutics has represented the pinnacle of authority and accuracy in describing the actions and uses of therapeutic agents in relation to physiology and pathophysiology. The text's careful balance of basic science and clinical applications has guided thousands of health care practitioners and students to a clear understanding of the drugs essential to preventing, diagnosing and treating disease. This Fourteenth Edition includes five new chapters, 600+ illustrations, and important content from 53 new contributors. More than a textbook, Goodman & Gilman’s is a working template for the effective and rational prescribing of drugs in daily practice. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics, Fourteenth Edition features: Five NEW chapters on: -Pharmacovigilance -The blood-brain barrier -Cannabis -Antibodies, immune checkpoint inhibitors, CAR-T cells, and other biological agents -Gastrointestinal microbiome and drug response Expanded coverage of the use of genetic polymorphisms in designing appropriate therapies Revised and expanded chapter on pharmacodynamics and the molecular mechanisms of drug action 600+ color illustrations Drug Fact Tables summarizing clinical pharmacology Content Outline and Abbreviation List at the beginning of each chapter 50 NEW figures on mechanism of drug actions 53 NEW contributors NEW online updates
600			_xMedical / Dentistry / General, Drug Therapy, Medical / Pharmacology, Pharmaceutical Preparations, Pharmacological Phenomena, Chemotherapy, Drugs, Pharmacokinetics.
700			_qBjorn Knollmann
942			_2ddc _cEB _n0
999			_c29536 _d29536