000			03461nam a22003017a 4500
001			20241031103116.0
003			OCoLC
005			20241031103506.0
008			241031b |||||||| |||| 00| 0 eng d
010			_a 2015946100
020			_a978-3-319-22538-8
020			_a978-3-319-22539-5 (eBook)
022			_a 0927-3042
040			_cddc
041			_aEnglish
100			_qHoward L. Kaufman
222			_aAcad Dermatol acral activity adjuvant advanced melanoma AJCC analysis Ann Surg Oncol antibody antigen associated benign biochemotherapy BRAF inhibitors BRAF-mutant brain metastases carboplatin cells chemotherapy Clin Cancer Res Clin Oncol clinical trials combination confocal confocal microscopy cutaneous melanoma dabrafenib dacarbazine demonstrated dermoscopy detection diagnosis dose Engl evaluation excision gene genetic high-risk imaging immune immunotherapy improved increased inhibition interferon ipilimumab kinase lesions lymph node biopsy lymphadenectomy lymphocytes malignant melanoma MAPK median MEK inhibitor melanoma patients Melanoma Res metastatic disease metastatic melanoma microscopy months mucosal melanoma mutations nevus nodal optical coherence tomography overall survival paclitaxel pathway patients with melanoma patients with metastatic pediatric melanoma peptide phase III trial pigmented prognostic radiotherapy randomized recurrence regimen reported resection response rate sentinel lymph node sentinel node skin cancer SLNB spitzoid stage subtype sun exposure surgical T-cell targeted therapies temozolomide tissue toxicity trametinib treated treatment tumor uveal melanoma vaccines vemurafenib versus vivo
245			_a Melanoma.
260			_aLondon | _b Springer International Publishing Switzerland | _c 2016
300			_a413 Pages
300			_aIncludes References
490			_aCancer Treatment and Research
520			_aMelanoma is one of the most types of cancer. When melanoma is detected at an early stage, treatment is highly successful, but outcomes can be poor when the disease is advanced. There has been significant progress in our understanding of the molecular biology, genetics, and immunology of melanoma over the past decade. This has been accompanied by rapid advances in therapeutic strategies for patients with melanoma. This book provides the clinician and the researcher with a broad understanding of the molecular and cellular pathogenesis of melanoma, explores the clinical characteristics and criteria for clinical and pathological staging of the disease, and provides an overview of current and evolving treatment strategies in the adjuvant, metastatic, and preventive settings. The treatment of special populations and rare variants of melanoma that often present particular clinical challenges is also covered. Authored by international experts in melanoma biology and clinical management, this volume concisely explains how to diagnose, treat, and prevent melanoma while reviewing advances in basic science and providing an overview of innovative approaches still under development.
600			_x Dermatology, Medical / Clinical Medicine, Medical / Dermatology, Medical / Oncology / General, Medical / Pediatrics, Medical / Surgery / General, Oncology, Pediatrics, Surgery, Medical / Oncology / Skin Cancer, Medicine, Melanoma.
700			_q Janice M. Mehnert
856			_uDOI 10.1007/978-3-319-22539-5
942			_2ddc _cEB _n0
999			_c29486 _d29486