000			02761nam a22002657a 4500
001			20241025114206.0
003			OCoLC
005			20241025114624.0
008			241025b |||||||| |||| 00| 0 eng d
010			_a 2016934318
020			_a978-4-431-56022-7
020			_a978-4-431-56024-1 (eBook)
040			_cddc
041			_aEnglish
082			_a616.994 071 MAR
100			_qYoshiro Maru
245			_aInflammation and Metastasis
260			_aDepartment of Pharmacology Tokyo Women’s Medical University Tokyo, Japan | _b Springer Japan | _c2016
300			_a515 Pages
300			_aIncludes References and Index
520			_aThis book provides the latest information on cancer metastasis from the standpoint of inflammation, especially innate immune reactions caused by endogenous mediators but not exogenous pathogens, with ideas on how to understand the complicated mechanisms of metastasis as well as to interpret therapeutic targets. The book includes the topic of the emerging roles of endogenous TLR4 ligands whose functions are shared intriguingly by metastasis and auto-inflammatory diseases such as rheumatoid arthritis. For example, most cancer therapies established so far are effective initially. However, they eventually face the great obstacles of drug resistance, immune evasion, and metastatic progression. One of the endogenous TLR4 ligands is thought to contribute to all three processes. The most important features of the book are to explain a concept of homeostatic inflammation, disturbance of which in the lungs gives rise to the establishment of a pre-metastatic pulmonary microenvironment based on primary tumor-mediated hijacking of the innate immune defense system against respiratory infection. In addition, structure-based thinking is another important feature of this book. It is proposed that inflammation forms a functional triangle with angiogenesis and coagulation, in the center of which cancer is located. Given the proposal of precision medicine by President Obama in the United States in 2015 and the recent success of immune-modulator-based therapy, this book will appeal to researchers in a variety of fields with the title of the book connecting the worst disease (metastasis) and the most fundamental event (inflammation) that is common to many diseases.
600			_xCancer, Human physiology, Immunology, Medical / General, Medical / Immunology, Medical / Oncology / General, Medical / Physiology, Medical / Diseases, Science / Life Sciences / Human Anatomy & Physiology, Biomedicine, Cancer -- Molecular aspects -- Immunological aspects, Cancer -- Research, Inflammation, Medicine, Metastasis, Oncology.
856			_u DOI 10.1007/978-4-431-56024-1
942			_2ddc _cEB _n0
999			_c29333 _d29333