000			02781nam a22002537a 4500
001			20241009174214.0
003			OCoLC
005			20241009174659.0
008			241009b |||||||| |||| 00| 0 eng d
020			_a978-3-030-56266-3
020			_a 978-3-030-56267-0
040			_cddc
041			_aEnglish
082			_a616.994 WON
100			_qFranklin C. L. Wong
245			_aLocoregional Radionuclide Cancer Therapy _bClinical and Scientific Aspects.
260			_aUniversity of Texas, M. D. Anderson Cancer Center Houston, TX USA | _bSpringer Nature Switzerland AG | _c 2021
300			_a271 Pages
300			_aIncludes References and Index
520			_a This book reviews locoregional radionuclide cancer therapies (LRCT). Proving an increasingly viable alternative to radiotherapy, radionuclide therapy includes a diversity of choices of well characterized biochemical and physiologic target molecules. The delivery and retention of radionuclides may be monitored by advanced imaging for exact tissue localization and for real-time dosimetry to enable personalized precision medicine. Radiopharmaceuticals in human cancer therapies are typically delivered in systemic routes but can also be designed for locoregional routes to harness pharmacokinetic advantages of higher payload and lower systemic toxicities. This book explores the latest advancements and clinical considerations of the locoregional approach. Throughout the chapters, the clinical and scientific bases of cancer treatment and the locoregional use of radionculides are explored. Mathematical models of radiation dosimetry of locoregional radionculdies on tissues are studied using common models for multiple commercially available radionuclides. Rodent and canine tumor models of LRCT are compared for selected radionuclides and radiopharmaceuticals. The practical aspects of radiopharmaceuticals production, marketing, transport, as well as radiation protection are reviewed. Finally, the combination of LRCT with immunotherapy and other cancer therapies and prospective future use of LRCT are discussed. This is a guide for practicing nuclear physicians, interventional radiologists, radiation oncologists, radiation scientists, veterinarians and oncologists to expand their knowledge base and to prepare for designing locoregional radionuclide cancer therapies in animals and in humans.
600			_x Internal medicine, Medical / Allied Health Services / Imaging Technologies, Medical / Biochemistry, Medical / Clinical Medicine, Medical / Internal Medicine, Medical / Radiology, Radiotherapy & Nuclear Medicine, Nuclear medicine, Radiology, Cancer -- Radiotherapy, Radiopharmaceuticals
856			_u https://doi.org/10.1007/978-3-030-56267-0
942			_2ddc _cEB _n0
999			_c29106 _d29106