000			02194nam a22002777a 4500
001			20241002094359.0
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008			241002b |||||||| |||| 00| 0 eng d
010			_a 2017954301
020			_a978-3-319-68037-8
020			_a 978-3-319-68038-5
040			_cddc
041			_aEnglish
082			_a 616.994 061 IMB
100			_qPaul Imbach
245			_a Antibody Therapy _bSubstitution – Immunomodulation – Monoclonal Immunotherapy
260			_aMedical Faculty of the University of Basel Basel Switzerland | _bSpringer International Publishing AG, part of Springer Nature | _c 2018.
300			_a361 Pages
300			_aIncludes References
490			_a https://doi.org/10.1007/978-3-319-68038-5
520			_aThis practical manual, written by well-known experts, reviews current indications for the use of IgG concentrates and some other modern immunomodulators and provides fundamental information on present-day immunomodulation in patients (and mice). The book opens by tracing the transition from IgG substitution to IgG immunomodulation and providing expert updates on immunomodulatory indications in autoimmune and inflammatory disorders, including hematologic, neurologic, dermatologic, and other diseases. Basic aspects of IgG concentrates, including methods of production, safety, currently available products, and mechanisms of action, are then discussed. An entire chapter is devoted to the different aspects of immunomodulatory IgG treatment in the bleeding disorder immune thrombocytopenia (ITP). Finally, the transition from polyclonal to monoclonal antibody (mAb) treatment is addressed in detail, covering mAb development, methods, mechanisms of action, adverse effects, and more. Particular attention is paid to the example of anti-CD20 (B-cell) antibody.
600			_xHematology, Immunology, Internal medicine, Medical / Clinical Medicine, Medical / Hematology, Medical / Immunology, Medical / Internal Medicine, Biological response modifiers, Immunoglobulins -- Therapeutic use, Medicine, Oncology.
856			_u https://doi.org/10.1007/978-3-319-68038-5
942			_2ddc _cEB _n0
999			_c29008 _d29008