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001			20240913110944.0
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028			_bWurzburg Road 35, Premises, Post Code: 33102 |
028			_b P. O. Box 1464 Mwanza, Tanzania |
028			_b Phone: (255) 28-298-3384 |
028			_b Fax: (255) 28-298-3386 |
028			_b Email: vc@bugando.ac.tz |
028			_b Website: www.bugando.ac.tz.
040			_cddc
041			_aEnglish
041			_aKiswahili
100			_eCUHAS/MD/4002747/T/19 _qAgape P. Barugahale.
245			_aPrevalence of Patent Ductus Arteriosus and Treatment Outcome Among Neonates Admitted at Bugando Medical Centre.
260			_aMwanza, Tanzania | _bCatholic University of Health and Allied Sciences [CUHAS-Bugando] | _c2024.
300			_a42 Pages
300			_aIncludes References
520			_aAbstract: Introduction: Patent Ductus Arteriosus (PDA) is one of the most common congenital heart diseases (CHDs) in infants accounting 5% to 10% of all CHDs, associated with high rate of morbidity and mortality. Despite a wide range of pharmacological management (widely used Indomethacin, ibuprofen and acetaminophen) and surgical interventions which may benefits several infants, there is increasing treatment controversy varying markedly between institutions and health care providers. Therefore, this study aimed at determining the prevalence of PDA and outcome of neonates treated with Acetaminophen in Mwanza, Tanzania Methodology: A hospital based retrospective study reviewing neonatal data from January to August 2024 in Bugando Medical Centre (BMC) was conducted. A total of 304 neonatal records were extracted in the study by random sampling. Data collection and entry was done using Eppicollect5 application where demographic information and relevant clinical data like, mode of delivery, vitals, reason for admission, ECHO findings before and after treatment, duration of hospital stay and outcome were obtained from patient’s file. SPSS Software version 20 was used for data analysis. Results: A total of 304 neonates’ records were analysed. The Median age of enrolled neonates was 1(IQR:1-22) and more than half,169(55.6%) were male. The prevalence of PDA among all neonates admitted was 18(5.9%). The prevalence of PDA among neonates with congenital heart diseases was 18(64.3%). The treatment outcome of neonates with PDA after seven days on acetaminophen, ECHO report revealed 12(66.7%) neonates attained full closure, and 2(11.1%) had small PDA. 3(16.7%) died before evaluation ECHO. However, by using Chi squared test no predictors for PDA closure were found in this study. Conclusion: PDA is the most common congenital heart defect in our setting, with good response to acetaminophen treatment. This request for prompt evaluation and intervention to all neonates at risk. However, in this study there was no predictors for early PDA closure.
600			_xAnatomy and Histology
600			_xMicrobiology & Immunology
700			_qNdulu Ishigita Magele
700			_qHelmut Adrian Nyawale
856			_zResearch Report Submitted in Partial Fulfillment for the Award of Doctor of Medicine degree of the Catholic University of Health and Allied Science.
942			_2ddc _cCR _n0
999			_c28702 _d28702