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008			240903b |||||||| |||| 00| 0 eng d
028			_bWurzburg Road 35, Premises, Post Code: 33102 |
028			_b P. O. Box 1464 Mwanza, Tanzania |
028			_b Phone: (255) 28-298-3384 |
028			_b Fax: (255) 28-298-3386 |
028			_bEmail: vc@bugando.ac.tz |
028			_bWebsite: www.bugando.ac.tz.
040			_cddc
041			_aEnglish
041			_aKiswahili
100			_e CUHAS/MD/4004029/T/19 _q Luchagula K. Victory.
245			_aPrevalence and Associated Risk Factors for Liver Stiffness among Patients with Chronic Hepatitis B Infection Using Fibroscan at Bugando Medical Centre.
260			_aMwanza, Tanzania | _bCatholic University of Health and Allied Sciences [CUHAS-Bugando] | _c2024.
300			_a31 Pages
300			_aIncludes References
520			_aAbstract: Background: Chronic hepatitis B is a significant global health concern, and liver fibrosis is a common complication. This study aimed to determine the prevalence of liver stiffness in Tanzanian CHB patients and identify the associated risk factors. Methods: A cross-sectional study of consecutive chronic hepatitis B patients performed VCTE and followed up at BMC Hospital, Mwanza, Tanzania, was conducted between 1 November, 2023, and 26 August, 2024. Liver fibrosis was defined as minimal (METAVIR F0-1) by LSM≤ 7.0 kPa and significant (METAVIR F2-4) by LSM ≥ 7.1 kPa. LSM assessments and medical records were retrospectively reviewed. The prevalence and determinants of significant liver fibrosis were analyzed. Results: A total of 211 eligible patients were included; 143 patients (67.8%) were male. The mean age was 41.41 years (SD 10.92 years), and 57.3% had a body mass index ≥ 25 kg/m2. The prevalence of significant fibrosis (F2-4) were 44.1%. Significant determinants of significant fibrosis (F2-4) were male gender, advanced age and elevated liver biochemistries. Conclusion: Approximately half of the Tanzanian patients with chronic viral hepatitis B had significant liver disease defined by Fibroscan, requiring further evaluation for specific treatment for hepatitis B virus. Determinants of significant liver fibrosis were male gender and high AST level.
600			_xInternal Medicine
600			_xBiochemistry & Molecular Biology
700			_qSemvua Bukheti Kilonzo
700			_qHyasinta Michael Jaka
700			_qFelix Abdallah Tarimo
856			_zResearch Report Submitted for Partial Fulfillment of The Requirements for The Award of Bachelor of Doctor of Medicine at The Catholic University of Health and Allied Sciences.
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