000			03024nam a22002657a 4500
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020			_a 978-3-319-16303-1
020			_a978-3-319-16304-8
040			_cddc
041			_aEnglish
100			_qMichael Ola Idowu
245			_aMolecular Oncology Testing for Solid Tumors _bA Pragmatic Approach
260			_a Switzerland : _bSpringer International Publishing : _c2015
300			_a738 Pages _bIncludes References and Index
490			_aDOI 10.1007/978-3-319-16304-8
520			_aFamiliarity with and understanding molecular testing is becoming imperative for practicing physicians, especially pathologists and oncologists given the current explosion of molecular tests for diagnostic, prognostic and predictive indications. Molecular Oncology Testing for Solid Tumors is designed to present an up to date practical approach to molecular testing in a easy to understand format. Emphasis is placed on quality assurance (pre-analytic, analytic and post-analytic) and test interpretation, including but not limited to: the important role of pathologists in ensuring specimen adequacy for molecular testing; factors to consider in choosing platforms for molecular assays; advantages and limitations inherent to common assays/platforms that pathologists need to communicate effectively with clinicians; the importance of required quality assurance measures to ensure accurate / reproducible results; pitfalls in test interpretation (including different types of artifacts that may lead to False Positive or False Negative interpretations); test reporting using standard nomenclature; review of the current and future potential utility of next-generation sequencing in oncology. All chapters are written by pathologists and clinicians experienced in practical applications of molecular tests for solid tumors. The uniqueness of this textbook is the use of a standardized template for each of the molecular tests being discussed followed by a discussion of relevant quality assurance issues to ensure focused and efficient presentation of information. This will enable readers to easily understand the Order, Report and Evaluate (ORE) process of molecular tests. Lastly, summary tables of all the molecular assays and mutations discussed in the text are provided as an appendix for quick reference. For readers interested in more detailed information, a link to websites where additional information can be obtained is provided.
600			_xMedical / Clinical Medicine, Medical / Oncology / General, Medical / Pathology, Oncology, Pathology, Cancer -- Diagnosis, Cancer -- Molecular diagnosis -- Molecular aspects, Medicine, Medicine and Public Health, Tumors -- Molecular aspects.
700			_qCatherine Isabelle Dumur
700			_q Carleton Theodore Garrett
856			_uDOI 10.1007/978-3-319-16304-8 _yDOI 10.1007/978-3-319-16304-8
942			_2ddc _cEB _n0
999			_c28312 _d28312