| 000 | 02353nam a22003137a 4500 | ||
|---|---|---|---|
| 001 | 20240610111235.0 | ||
| 003 | 20240610111235.0 | ||
| 005 | 20240610112111.0 | ||
| 008 | 240610b |||||||| |||| 00| 0 eng d | ||
| 040 | _cddc | ||
| 041 | _aEnglish | ||
| 100 | _qJenipher G. Mwakyabala | ||
| 245 | _aCharacterisation of genes encoding for extended spectrum β-lactamase in Gram-negative bacteria causing healthcare-associated infections in Mwanza, Tanzania | ||
| 260 |
_aMwanza, Tanzania : _bCatholic University of Health and Allied Sciences [CUHAS-Bugando] : _c2023 |
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| 300 | _aIncludes References | ||
| 490 | _vAfrican Journal of Laboratory MedicineVol. 12, No. 1 | ||
| 520 | _aAbstract : Healthcare-associated infections (HCAIs) caused by extended spectrum β-lactamase-producing Gram-negative bacteria (ESBL-GNB) increase morbidity and mortality. This cross-sectional study characterised ESBL genes (blaCTX-M, blaTEM and blaSHV) among 30 ceftriaxone-resistant GNB causing HCAIs between January 2022 and July 2022 by multiplex polymerase chain reaction assay at the zonal referral hospital in Mwanza, Tanzania. Twenty-five (83.3%) had at least one ESBL gene, of which 23/25 (92.0%) carried the blaCTX-M gene. Seventy-two percent (18/25) of the GNB-ESBL isolates carried more than one ESBL gene, of which the majority (88.8%; n = 16/25) carried the blaCTX-M and blaTEM genes. Extended spectrum β-lactamase genes, particularly blaCTX-M, are common among ceftriaxone-resistant GNB causing HCAIs. What This Study Adds :This study revealed the distribution of genes (blaCTX-M, blaTEM and blaSHV) coding for ESBL production among ceftriaxone resistant GNB causing HCAIs However, all ESBL producing GNB were susceptible towards ceftriaxone-sulbactam indicating that ceftriaxone-sulbactam may be empirically prescribed for treating patients with HCAIs. | ||
| 600 | _xbeta lactamases | ||
| 600 | _xextended spectrum beta-lactamase | ||
| 600 | _xGram-negative bacteria | ||
| 600 | _xhealthcare-associated infections | ||
| 600 | _xmultiplex PCR assay | ||
| 700 | _qConjester I. Mtemisika | ||
| 700 | _q Stacy Mshana | ||
| 700 | _qAdam A. Mwakyoma | ||
| 700 | _q Vitus Silago | ||
| 856 |
_uhttps://hdl.handle.net/10520/ejc-ajlab_v12_n1_a2107 _yhttps://hdl.handle.net/10520/ejc-ajlab_v12_n1_a2107 |
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| 942 |
_2ddc _cVM _n0 |
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| 999 |
_c28013 _d28013 |
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