| 000 | 02625nam a22003257a 4500 | ||
|---|---|---|---|
| 001 | 20240607200749.0 | ||
| 003 | 20240607200749.0 | ||
| 005 | 20240607201345.0 | ||
| 008 | 240607b |||||||| |||| 00| 0 eng d | ||
| 040 | _cddc | ||
| 041 | _aEnglish | ||
| 100 | _qGovindaraju Ramkumar | ||
| 245 | _a Overexpression of cytochrome P450 and esterase genes involved in permethrin resistance in larvae and adults of Culex quinquefasciatus | ||
| 260 |
_aMwanza, Tanzania : _bCatholic University of Health and Allied Sciences [CUHAS-Bugando] : _c2023 |
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| 300 | _aPages 3205–3212 | ||
| 300 | _aIncludes References | ||
| 490 | _v Parasitol Res 122, 3205–3212 (2023). | ||
| 520 | _aAbstract : Mosquitoes are important vectors of several arthropod-borne diseases, which remain a priority for epidemiological research. Mosquito vector control strategies have traditionally relied on chemical insecticides such as synthetic pyrethroids. However, the indiscriminate use of pesticides has resulted in the development of resistance in many mosquito species. In insects, resistance evolves primarily through the overexpression of one or more gene products from the cytochrome P450, carboxylesterase, and glutathione superfamilies. The current study examined the expression of cytochrome P450 CYP6M2, CYP6AA7, CYP6Z2, CYP9J34, α-Esterase, Esterase B1, and neuroactin genes in larvae and adults of a permethrin-resistant (PerRes) and susceptible (Sus) Culex quinquefasciatus strains. The results showed that the CYP6AA7 gene was overexpressed (10-fold) in larvae and adults with PerRes (p < 0.01) followed by CYPJ34 (9.0-fold) and CYP6Z2 (5.0-fold) compared to the Sus, whereas fewer changes in CYP6M gene expression were observed in PerRes adults (p < 0.05), and no expression was found in larvae. The esterase gene was overexpressed in PerRes larvae (9.0-fold) followed by adults (2.5-fold) compared to the susceptible strain. Based on data, the present study suggests that cytochrome P450, CYP6AA7, CYP6Z2, CYP9J34, α-Esterase, Esterase B1, and neuroactin genes were involved in permethrin resistance in larval and adult Cx. quinquefasciatus. | ||
| 600 | _xCulex quinquefasciatus | ||
| 600 | _x Permethrin resistance | ||
| 600 | _xqRT-PCR | ||
| 600 | _xSynthetic pyrethroid | ||
| 600 | _xEnzyme overexpression | ||
| 700 | _qRanganathan Muthusamy | ||
| 700 | _qMathiyazhagan Narayanan | ||
| 700 | _qMuthugoundar Subramanian Shivakumar | ||
| 700 | _qEliningaya J. Kweka | ||
| 856 |
_uhttps://doi.org/10.1007/s00436-023-08010-2 _yhttps://doi.org/10.1007/s00436-023-08010-2 |
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_2ddc _cVM _n0 |
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_c27992 _d27992 |
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