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008			240607b |||||||| |||| 00| 0 eng d
040			_cddc
041			_aEnglish
100			_qFrédéric B Piel
245			_aDefining global strategies to improve outcomes in sickle cell disease _ba Lancet Haematology Commission
260			_aMwanza, Tanzania : _bCatholic University of Health and Allied Sciences [CUHAS-Bugando] : _c2023
300			_aPages 633-686,
300			_aIncludes References
490			_v The Lancet Haematology Commissions| Volume 10, Issue 8, E633-E686, August 2023
520			_aAll over the world, people with sickle cell disease (an inherited condition) have premature deaths and preventable severe chronic complications, which considerably affect their quality of life, career progression, and financial status. In addition, these people are often affected by stigmatisation or structural racism, which can contribute to stress and poor mental health. Inequalities affecting people with sickle cell disease are also reflected in the distribution of the disease—mainly in sub-Saharan Africa, India, and the Caribbean—whereas interventions, clinical trials, and funding are mostly available in North America, Europe, and the Middle East. Although some of these characteristics also affect people with other genetic diseases, the fate of people with sickle cell disease seems to be particularly unfair. Simple, effective interventions to reduce the mortality and morbidity associated with sickle cell disease are available. The main obstacle preventing better outcomes in this condition, which is a neglected disease, is associated with inequalities impacting the patient populations. The aim of this Commission is to highlight the problems associated with sickle cell disease and to identify achievable goals to improve outcomes both in the short and long term.
600			_xsickle cell disease
700			_q David C Rees
700			_qMichael R DeBaun
700			_qObiageli Nnodu
700			_qBrigitte Ranque
700			_qAlexis A Thompson
700			_qRussell E Ware
700			_qMiguel R Abboud
700			_qAllistair Abraham
700			_qLillian Sung
700			_qLeon Tshilolo
700			_qDiana J Wilkie
700			_qKwaku Ohene-Frempong
700			_qEmmanuela E Ambrose
700			_q Biree Andemariam
700			_qRoshan Colah
700			_qRaffaella Colombatti
700			_qNicola Conran
700			_qFernando F Costa
700			_qRobert M Cronin
700			_qMariane de Montalembert
700			_qJacques Elion
700			_qErica Esrick
700			_qAnthea L Greenway
700			_q Ibrahim M Idris
700			_qDavid-Zacharie Issom
700			_qLori C Jordan
700			_qZane S Kaplan
700			_qAllison A King
700			_qMichele Lloyd-Puryear
700			_qSamuel A Oppong
700			_qAkshay Sharma
856			_uhttps://doi.org/10.1016/S2352-3026(23)00096-0 _yhttps://doi.org/10.1016/S2352-3026(23)00096-0
942			_2ddc _cVM _n0
999			_c27989 _d27989