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022			_a1471-2458
040			_cddc
041			_aEnglish
100			_qHilda J. Tutuba
245			_aThe efficacy of maternal health education and maternal screening on knowledge and the uptake of infant screening for sickle cell disease in Dar-Es-Salaam, Tanzania _ba quasi-experimental study
260			_aMwanza, Tanzania : _bCatholic University of Health and Allied Sciences [CUHAS-Bugando] : _c2023
300			_aPages 01-12
300			_aIncludes References
490			_vBMC Public Health volume 23, Article number: 70 (2023)
520			_aAbstract : Background : Globally, Sickle cell disease (SCD) is one of the most common genetic disease with high childhood mortality. Early identification of babies with SCD through newborn screening (NBS) and linking them to care are among the recommended interventions. The purpose of this study was to assess the efficacy of maternal health education and maternal screening for SCD on knowledge and the uptake of infant screening for SCD among mother-infant pairs attending antenatal clinics at Government health facilities in Dar-es-salaam, Tanzania. Methods : This study was a pre-test post-test, quasi-experimental which involved pregnant women attending antenatal clinics at three hospitals; Mbagala hospital, Sinza hospital and Buguruni health center in Dar Es Salaam. A structured questionnaire was used in data collection. Knowledge on SCD was assessed for all participants before and after two sessions of health education. Participants in Mbagala and Buguruni were also screened for SCD using Sickle SCAN point-of-care test (BioMedomics Inc, USA). The efficacy for health education intervention was computed as the post-intervention minus baseline knowledge score. For proportions, a two-sample z-test was used. Univariate and multivariate logistic regression were used to analyze the efficacy of health education intervention and also predictors of infant diagnosis. Results : For two sessions of health education intervention, a total of 467 pregnant women completed the sessions. During antenatal visits, a total of 218 were screened for SCD. The proportion of participants with good knowledge of SCD had significantly increased to 85.9% from 12.4% at baseline following the education intervention. In multivariate analysis, sharing the received education on SCD was an independent predictor of the efficacy of health education intervention. Maternal occupation, maternal SCD status as well as sharing the received education on SCD were independent predictors of the uptake of SCD infant diagnosis. Conclusion : This study has demonstrated that maternal health education and maternal screening for SCD are feasible and efficacious interventions in raising knowledge and improving the uptake of infant diagnosis for SCD. These interventions are strongly recommended to be included in the comprehensive care package for pregnant women attending antenatal clinics, particularly in areas with a high burden of SCD.
600			_x Sickle cell disease (SCD)
600			_x Efficacy
600			_xHealth education
600			_xMaternal screening for SCD
600			_x Intervention
600			_x Knowledge
600			_xInfant screening
700			_qEmmanuel Balandya
700			_q Irene K. Minja
700			_q Benson R. Kidenya
700			_qPaschal Ruggajo
700			_qJulie Makani
700			_qEmanuela Marco
700			_q Upendo Masamu
700			_qWilliam Lloyd
700			_qAgnes Jonathan
856			_uhttps://doi.org/10.1186/s12889-022-14859-2 _yhttps://doi.org/10.1186/s12889-022-14859-2
942			_2ddc _cVM _n0
999			_c27970 _d27970