000			02685nam a22003017a 4500
001			20240606191811.0
003			20240606191811.0
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022			_aISSN 2045-2322 (online)
040			_cddc
041			_aEnglish
100			_dPrisca Damiano
245			_aEfficacy of disinfectants on control and clinical bacteria strains at a zonal referral hospital in Mwanza, Tanzania _b a cross sectional hospital-based study
260			_aMwanza, Tanzania : _b Catholic University of Health and Allied Sciences [CUHAS – Bugando] : _c2023
300			_aPages 01-07
300			_aIncludes References
490			_aSci Rep 13, 17998 (2023).
520			_aAbstract : Contaminated-hospital surfaces are an important source of pathogenic bacteria causing health-care associated infection (HCAIs). Monitoring the performance of disinfectants that are routinely used to clean hospital surfaces is critical for prevention and control of HCAIs. Nevertheless, the evaluation of the performance of disinfectants and their efficacy are not routinely practiced in most resource-limited countries. This study was designed to determine the efficacy of sodium dichloroisocyanurate (NaDCC) and chloroxylenol against American Type Culture Collection (ATCC) and their respective multidrug resistant (MDR) strains causing neonatal sepsis at a zonal referral hospital in Mwanza, Tanzania. Four ATCC (n = 4) and their respective MDR strains of Klebsiella pneumoniae, Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa were used. The suspension test was used with contact time of 1, 5 and 10 min with starting concentration of 105 bacterial colony forming unit per milliliters (CFU/mL). The log10 reduction value at specified bacteria-disinfectant contact time was used to assess the efficacy of 0.5%NaDCC and 4.8% chloroxylenol in-use and freshly prepared solutions. In-use 0.5%NaDCC demonstrated poor log reduction (˂ 5log) against MDR-clinical isolates. Freshly laboratory prepared 0.5% NaDCC had 100% microbial reduction at 1, 5 and 10 min of both ATCC and MDR strains up to 48 h after preparation when compared with freshly prepared 4.8% chloroxylenol (˂ 5log). Freshly, prepared 0.5% NaDCC should be used in health-care facilities for effective disinfection practices.
700			_qVitus Silago
700			_q Helmut A. Nyawale
700			_qMartha F. Mushi
700			_qMariam M. Mirambo
700			_qEmmanuel E. Kimaro
700			_qStephen E. Mshana
856			_uhttps://doi.org/10.1038/s41598-023-45228-7 _yhttps://doi.org/10.1038/s41598-023-45228-7
942			_2ddc _cVM _n0
999			_c27946 _d27946