000			02924nam a22003497a 4500
001			CUHAS/BP/3000175/T/14
003			CUHAS/BP/3000175/T/14
005			20240305193858.0
008			210811b |||||||| |||| 00| 0 eng d
028			_bWurzburg Road 35, BMC Premises, Post Code: 33102:
028			_bP. O. Box 1464, Mwanza – Tanzania:
028			_bPhone: +255 28 298 3384:
028			_bFax: +255 28 298 3386:
028			_bEmail: vc@bugando.ac.tz :
028			_b www.bugando.ac.tz
035			_aCUHAS/BP/3000175/T/14
040			_bEnglish _cDDC
041			_aEnglish
041			_aKiswahili
100			_aShayo, Maria. S _921516 _dCUHAS/BP/3000175/T/14
245			_a In vitro antifungal activities of Allium Sativum (garlic) against Candida albicans clinical isolates in Mwanza, Tanzania.
260			_aMwanza, Tanzania : _bCatholic University of Health and Allied Sciences [CUHAS - Bugando] : _c©2018
300			_aviii; 17 Pages
300			_aIncludes References
520			_aAbstract: Background: Allium sativum contain the active chemical compounds such as Allicin and Ajoen. Antimicrobial anti-cancer and anti-thrombotic effect of Allium sativum have been documented previously C. Albicans is the leading opportunistic fungi pathogen with limited drug of choice. In Tanzania treatment of candidiasis main rely on azoles. The emergence of azole resistant among C. albicans call for the need of discovering new antifungal agents. The current study was conducted to evaluate the effect of Allium sativum on Candida albicans. Method: It was laboratory experimental analysis which conducted from May to August 2018 which included 20 archived of Candida albicans. By agar dilution method Muller Hinton supplement with garlic extract of different concentrations were prepared following standard microbiological techniques. The plates containing Muller Hinton agar + Garlic were inoculated with C. Albicans isolates and incubated under appropriate conditions. The plate with growth was considered as resistant whereas minimum concentration that inhibits growth was recorded as MIC. Results: In the current study C. albicans grew at the concentration of 2.5mg/ml up to 20mg/ml. At the concentration of 25mg/ml, 30mg/ml and 40mg/ml were 55% (11:20), 65% (13:20), 100% (20:20) and 100% (20:20) inhibit the growth respectively. The minimum inhibitory concentration was 35mg/ml. Conclusion: Allium sativum extract inhibited fungal growth at a concentration of 35mg/ml. So the result of this study provides scientific justification for the use of garlic extract in health products and herbal medicine in treating fungal ailment especially due to Candida albicans
600			_xPharmacy
600			_xMicrobiology & Immunology
600			_xBiochemistry and Molecular Biology
700			_aOkamo, Bernard _919703
700			_aMushi, Martha _919704
942			_2ddc _cCR
999			_c21371 _d21371