000			02745nam a22001937a 4500
001			CUHAS/BM/1000245/T/15
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100			_a Maiga, Lydia _d CUHAS/BM/1000245/T/15 _919714
245			_a Seroprevalence and Associated Factors of Herpes Simplex Virus Type 2 Among Women With Macerated Stillbirth in Mwanza Tanzania
260			_aMwanza, Tanzania: _bCatholic University of Health and Allied Sciences [CUHAS - Bugando] _bPhone: +255 28 298 3384 : _b Fax: +255 28 298 3386 : _b Email: vc@bugando.ac.tz : _bWebsite: www.bugando.ac.tz : _c ©2018
300			_a viii; 33 Pages
300			_aIncludes Refferences and Appendices
520			_aAbstract: Background and objectives: Stillbirth is a common problem in low and middle income countries whereby more than 55% of cases occurs in Sub Saharan Africa. Despite being common in the most of these countries etiologies of these cases was not been well studies. Herpes simplex virus -2 (HSV-2) has been implicated as one of the pathogens causing stillbirth. Despite being common in this region, there is limited information on its prevalence among women with macerated stillbirth. The aim of this study was to asses’ seroprevalence of HSV2 and associated factors among women with macerated still birth in Mwanza Tanzania. Methods: A cross sectional hospital based study involving 279 women with macerated stillbirth was conducted in Mwanza region from June to July 2018. Socio-demographic, obstetric and other relevant information were collected by pre tested structured data collection tool. Sera were tested for HSV-2 specific IgG and IgM antibodies using rapid Immunochromatographic test as per manufacturer’s instructions. Data analysis was done using STATA version 13 as per study objectives. Results: The median age of enrolled women was 27, IQR: 22-34 years and median gestation age 37, IQR: 34-38 weeks. Out of 279 women 28 (10.04%), 95% CI: 6.8-13.9) were HSV-2 IgG seropositive while out of 279 women 4 (1.43%, 95% CI: 0.03 – 2.8) were HSV-2 IgM seropositive. By multivariable logistic regression analysis only increase in age (OR: 0.93 95% CI: 0.87-0.99 P<0.003) was found to predict HSV-2 IgG seropositivity among women with macerated still birth in Mwanza Tanzania. Conclusion and Recommendations: The prevalence HSV-2 among women with macerated stillbirth in Mwanza is high and is predicted by decrease in age. Further studies to establish causal effect relationship are recommended in this setting.
600			_xMicrobiology and Immunology _948529
600			_xMedical Laboratory Sciences _948546
700			_a Mirambo, Mariam _919715
700			_a Mshana, Stephen. E _919716
942			_2ddc _cCR
999			_c20090 _d20090