000			02603nam a22003377a 4500
003			OSt
005			20240305193746.0
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028			_b Phone: +255 28 298 3384
028			_b Fax: +255 28 298 3386
028			_b Email: vc@bugando.ac.tz
028			_b Website: www.bugando.ac.tz
040			_bEnglish _cDLC
041			_aEnglish
100			_aKarl G Reis _946786
245			_aBlood pressure, T cells, and mortality in people with HIV in Tanzania during the first 2 years of antiretroviral therapy
260			_aMwanza, Tanzania: _bThe Journal of Clinical Hypertension & _bCatholic University of Health and Allied Sciences [CUHAS – Bugando] _c 20 August 2020
300			_aPages 1554-1562
490			_vThe Journal of Clinical Hypertension Volume 22 Issue 9
520			_a Abstract:: Cardiovascular disease is now a leading cause of mortality in people with HIV (PWH). High blood pressure is the major driver of cardiovascular disease. Despite this, little is known about blood pressure in PWH during the early years of antiretroviral therapy (ART). In this prospective cohort study in Tanzania, the authors conducted unobserved blood pressure measurements at enrollment, 3, 6, 12, 18, and 24 months in 500 PWH initiating ART and 504 HIV-uninfected adults. The authors excluded measurements taken on antihypertensive medications. Although PWH had a significantly lower blood pressure before ART initiation, they had a significantly greater increase in blood pressure during the first 2 years of ART compared to HIV-uninfected controls. Blood pressure correlates in PWH differed from HIV-uninfected controls. In PWH, lower baseline CD4+ T-cell counts were associated with lower blood pressure, and greater increases in CD4+ T-cell counts on ART were associated with greater increases in blood pressure, both on average and within individuals. In addition, PWH with a systolic blood pressure (SBP) <90 mm Hg at the time of ART initiation had ~30% mortality in the following 3 months due to occult infections. These patients require careful investigation for occult infections, and those with tuberculosis may benefit from corticosteroids.
700			_a Bernard Desderius _921235
700			_a Justin Kingery _946637
700			_aAnnet Kirabo _946634
700			_aAbel Makubi _946588
700			_a Christina Myalla _946787
700			_a Myung Hee Lee _945156
700			_a Saidi Kapiga _945137
700			_aRobert N Peck _922982
856			_uhttps://doi.org/10.1111/jch.13975
942			_2ddc _cVM
999			_c19944 _d19944