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022			_aOnline ISSN 1465-3664
028			_b Phone: +255 28 298 3384
028			_b Fax: +255 28 298 3386
028			_b Email: vc@bugando.ac.tz
028			_b Website: www.bugando.ac.tz
040			_bEnglish _cDLC
041			_aEnglish
100			_aAC Liwa _945987
222			_apara-aminosalicylic acid, pharmacokinetics, children
222			_a plasma drug concentration high pressure liquid chromatography procedure p-aminosalicylic acid
245			_aPara-aminosalicylic acid plasma concentrations in children in comparison with adults after receiving a granular slow-release preparation
260			_aMwanza, Tanzania: _bOxford University Press & _b Catholic University of Health and Allied Sciences [CUHAS – Bugando] _c2013/4/1
300			_aPages 90-94
490			_vJournal of tropical pediatrics Volume 59 Issue 2
520			_aAbstract:::: There are no paediatric data regarding slow-release para-aminosalicylic acid (PAS). We studied PAS plasma concentrations in 10 children receiving a single 150 mg/kg dose daily or 75 mg/kg twice daily and 12 adults receiving 4 g twice daily. Blood specimens pre-dose and 2, 4, 6, 8 and 12 h post-dose from the children and 2, 3, 4, 5, 6, 8 and 12 h post-dose from the adults were analysed by high performance liquid chromatography MS/MS. The mean Cmax in children receiving PAS 75 mg/kg and 150 mg/kg and adults receiving 4 g was 45.40, 56.49 and 51.3 µg/ml, respectively (p = 0.614); the AUC0–12 was 233.3, 277.9 and 368.0 µg/h/ml (p = 0.587). No parameters differed significantly between children and adults nor between the two doses in the same children. A 150 mg/kg PAS dosage given as one or two daily doses leads to plasma concentrations in children similar to those of adults receiving 4 g PAS twice daily.
700			_aHS Schaaf _945989
700			_aB Rosenkranz _945990
700			_aHI Seifart _945991
700			_aAH Diacon _945992
700			_aPR Donald _945993
856			_uhttps://doi.org/10.1093/tropej/fms053
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999			_c19705 _d19705