000			02804nam a22003257a 4500
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028			_b Phone: +255 28 298 3384
028			_b Fax: +255 28 298 3386
028			_b Email: vc@bugando.ac.tz
028			_b Website: www.bugando.ac.tz
040			_bEnglish _cDLC
041			_aEnglish
100			_aWilhelmina Mussa _945873
222			_aCandida Colonization, C. albicans, C. glabrata, Oral
245			_aCandida Colonization among Neonates with Low Birth Weight: There Is Much More to Explore
260			_aMwanza, Tanzania: _bScientific Research Publishing & _b Catholic University of Health and Allied Sciences [CUHAS – Bugando] _c2020/11/4
300			_aPages 626-634
490			_vOpen Journal of Pediatrics Volume 10 Issue 4
520			_aAbstract: Background and Objectives: Candida colonization in neonates with low birth weight is reported to be the first step for invasive candidiasis. This study was designed to describe the patterns of Candida spp. colonizing neonates with low birth weight in Mwanza, Tanzania to provide baseline information for future studies in this field. Methodology: The hospital based cross sectional study was conducted between January 2019 and April 2019 among neonates with low birth weight. Clinical and social demographic data were collected using interview guide questionnaire. Oral and umbilical rectal swabs were collected on the first and seventh day of life to assess Candida spp. colonization status. Data were analyzed using STATA version 13 following the study objectives. Results: A total of 320 neonates with median body weight of 1600 [IQR 1000 - 2000] grams were enrolled. Prevalence of Candida spp. colonization on either oral, umbilical or rectum was 16.2% (52/320). A total of 34 (10.6%) and 41 (12.8%) neonates were colonized by Candida spp. on the first day and seventh day of life, respectively. Of 34 neonates colonized on the first day of life, 23 (67.7%) were still being colonized on the seventh day. Candida albicans 38 (73.1%), was the predominant species detected followed by Candida glabrata 10 (19.2%). Conclusion: The prevalence of Candida spp. colonization among neonates with low birth weight is within the reported range and is mainly due to Candida albicans. Future studies are highly needed to explore the role of colonization and subsequent Candida spp. infections.
700			_aBenard Modest _945874
700			_aAdolfine Hokororo _922795
700			_aFlorentina Mashuda _922796
700			_aVitus Silago _919665
700			_aStephen E Mshana _915820
700			_aMartha F Mushi _919663
856			_uhttps://www.scirp.org/journal/paperinformation.aspx?paperid=104570
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999			_c19645 _d19645