000			03140nam a22003857a 4500
003			OSt
005			20240305193734.0
008			221123b |||||||| |||| 00| 0 eng d
022			_aEISSN 2076-2615
028			_b Phone: +255 28 298 3384
028			_b Fax: +255 28 298 3386
028			_b Email: vc@bugando.ac.tz
028			_b Website: www.bugando.ac.tz
040			_bEnglish _cDLC
041			_aEnglish
100			_aConjester I Mtemisika _923493
222			_aantimicrobial resistance; epidemiological cut-off values; Escherichia coli; poultry; pigs
245			_aEpidemiological Cut-Off Values and Multidrug Resistance of Escherichia coli Isolated from Domesticated Poultry and Pigs Reared in Mwanza, Tanzania: A Cross-Section Study
260			_aMwanza, Tanzania: _b MDPI & _b Catholic University of Health and Allied Sciences [CUHAS – Bugando] _c2022/3/25
300			_a Pages 835
490			_vAnimals Volume 12 Issue 7
520			_a Abstract: Increasing antimicrobial resistance (AMR) colonizing domesticated animals is a global concern threatening food safety. This study aimed at determining the prevalence of multidrug resistance (MDR) and epidemiological cut-off values (ECVs) of E. coli isolated from poultry and pigs in Mwanza, Tanzania. This cross-sectional study was conducted between June and August 2021, involving 297 pigs, 191 broilers, and 203 layers. Rectal and cloacal swabs were collected and processed following standard guidelines. ECVs were determined using normalized resistance interpretation (NRI), a computer software, and descriptive analysis was performed using STATA version 13.0. The overall prevalence of MDR E. coli was 63.2%, whereas poultry (87.5% layers and 86.3% broilers) were more colonized than pigs (31.8%) (p < 0.001). Based on ECVs of antibiotics tested, E. coli from broilers, layers, and pigs exhibited different resistance patterns hence different populations. Exotic breed (p < 0.001) and recent antimicrobial use (p < 0.001) significantly predicted colonization with MDR E. coli. Veterinary officers should implement regulations that prohibit the inappropriate use of antimicrobial agents in livestock keeping.
520			_a Simple Summary: The objectives of this study were to determine the prevalence of multidrug resistance phenotypes and the distribution of Escherichia coli among poultry and pigs. Laboratory procedures were conducted according to standard operating procedures and international guidelines. Our findings showed that poultry and pigs reared in Mwanza, Tanzania, are colonized with resistant bacterial phenotypes. Further, different populations of intestinal flora, E. coli, exist between poultry and pigs.
700			_a Helmut Nyawale _926655
700			_a Ronald J Benju _945837
700			_aJoseph M Genchwere _945838
700			_aVitus Silago _919665
700			_a Martha F Mushi _919663
700			_aJoseph Mwanga _923077
700			_a Eveline Konje _922961
700			_a Mariam M Mirambo _922927
700			_aStephen E Mshana _915820
856			_uhttps://doi.org/10.3390/ani12070835
942			_2ddc _cVM
999			_c19633 _d19633