000			03172nam a22004577a 4500
003			OSt
005			20240305193734.0
008			221123b |||||||| |||| 00| 0 eng d
022			_a EISSN 2414-6366
028			_b Phone: +255 28 298 3384
028			_b Fax: +255 28 298 3386
028			_b Email: vc@bugando.ac.tz
028			_b Website: www.bugando.ac.tz
040			_bEnglish _cDLC
041			_aEnglish
100			_aMariam M Mirambo _922927
222			_a Leptospira antibodies; adults; febrile; Mwanza
245			_aSeropositivity of Leptospira spp. Antibodies among Febrile Patients Attending Outpatient Clinics in Mwanza, Tanzania: Should It Be Included in Routine Diagnosis?
260			_aMwanza, Tanzania: _bMDPI & _bCatholic University of Health and Allied Sciences [CUHAS – Bugando] _c2022/8/9
300			_a Pages 173
490			_vTropical Medicine and Infectious Disease Volume 7 Issue 8
520			_a Abstract: Leptospirosis is a zoonotic neglected tropical disease with a worldwide distribution caused by the pathogenic spirochetes of the genus Leptospira. Despite being a widespread disease in tropical regions, it has never been considered in the routine diagnostic panel for febrile patients. This study determined seropositivity and factors associated with Leptospira antibodies among febrile adult patients in Mwanza, Tanzania. The cross-sectional study involving 296 febrile patients attending different outpatient clinics in Mwanza region was conducted between May and July 2019. Detection of Leptospira serovars antibodies was done using a microscopic agglutination test (MAT). Descriptive analysis was done using STATA version 13. The median age of the febrile patients was 32 (IQR: 24–45 years). Out of 296 patients, 36 (12.16%, 95%CI: 8–15) were seropositive for Leptospira antibodies. Common circulating serovars were Sokoine 28 (9.45%), followed by Lora 12 (4.05%) and Grippotyphosa 2 (0.67%). In the multivariable logistic regression analysis, the odds of being Leptospira seropositive were significantly higher with increased age (aOR: 1.03, 95%CI 1.00–1.07, p = 0.03). About one tenth of febrile patients in Mwanza were seropositive for Leptospira antibodies and this was significantly associated with age. With the decline of malaria fever in endemic areas, other causes of febrile illness like Leptospiral spp. should be considered in the routine diagnostic panel for febrile patients.
700			_aStephen E Mshana _915820
700			_a Georgies Mgode _945765
700			_a Lucas Matemba _923273
700			_aKhadija S Majid _945769
700			_a Elifuraha B Mngumi _945647
700			_aSubira S Mwakabumbe _945766
700			_aGinethon Mhamphi _945770
700			_a Namanya Basinda _919697
700			_a John Moses _945807
700			_aGabriel Emmanuel _921521
700			_a Vitus Silago _919665
700			_a Betrand Msemwa _919669
700			_a Helmut Nyawale _926655
700			_aMlekwa G Mgomi _945808
700			_a Julius M Madeu _945809
700			_a William S Nasson _945810
856			_uhttps://doi.org/10.3390/tropicalmed7080173
942			_2ddc _cVM
999			_c19627 _d19627