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028			_b Phone: +255 28 298 3384
028			_b Fax: +255 28 298 3386
028			_b Email: vc@bugando.ac.tz
028			_b Website: www.bugando.ac.tz
040			_bEnglish _cDLC
041			_aEnglish
100			_aNelly Mwageni _930498
222			_aLeprosy epidemiology case detection delay Tanzania
245			_aLeprosy epidemiological trends and diagnosis delay in three districts of Tanzania: A baseline study
260			_aMwanza, Tanzania: _b Leprosy Review & _b Catholic University of Health and Allied Sciences [CUHAS – Bugando] _c2022/9/1
300			_a Pages 209-223
490			_v Leprosy Review Volume 93 Issue 3
520			_aAbstract: Objectives: Leprosy, also known as Hansen’s disease, is a slowly progressive and chronic infectious neglected tropical disease (NTD) caused by Mycobacterium leprae. This study was performed to assess the epidemiological trend of leprosy in the past five years in the three study districts in Tanzania in which a leprosy prevention intervention study (PEP4LEP) is implemented, and to determine the case detection delay at baseline. Methods: Secondary data from the leprosy registry of the National Tuberculosis and Leprosy Program of Tanzania from 2015 to 2019 were used to describe the epidemiological trends of leprosy for the three study districts: Morogoro, Mvomero, and Lindi district council. A cross-sectional study was also conducted to assess the delay in leprosy diagnosis at baseline. The chi-square test was used to calculate statistical significance. Results: Between 2015 and 2019, 657 new leprosy cases were detected in three districts. Of those cases, 247 (37.6%) were female patients, 5 (0.8%) had a grade 2 disability (G2D) and 516 (78.5%) had multibacillary (MB) leprosy. From the 50 adult leprosy patients interviewed for detection delay, 16 (32.0%) were females and 38 (76.0%) had MB leprosy. Overall, a mean case detection of 28.1 months (95% CI 21.5–34.7) and a median of 21.5 months were observed. Conclusion: The three PEP4LEP study districts remain highly endemic, with long case detection delays observed that increase the risk of disabilities and contribute to ongoing leprosy transmission. Integrating activities such as contact screening and provision of post-exposure prophylaxis are therefore a necessary strategy in these endemic areas.
700			_a Stephen E Mshana _915820
700			_a Jan Hendrik Richardus _945686
700			_a Christa Kasang _923005
700			_aLiesbeth Mieras _945675
700			_aRobin van Wijk _945687
700			_aAnne Schoenmakers _945674
700			_aThomas Hambridge _945688
700			_aJohn E Masenga _945783
700			_a Saida Kidula _945784
700			_aReuben Hebron _945785
700			_a William Mayunga _945786
700			_aShigela Marco _945787
700			_a Abdallah Pegwa _945788
700			_aPhellister Nyakato _945789
700			_aDeusdedit Kamara _945790
700			_a Riziki Kisonga _945791
700			_a Blasdus Njako _945676
856			_uhttps://leprosyreview.org/article/93/3/20-22017
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