000			03295nam a22004097a 4500
003			OSt
005			20240305193733.0
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022			_aOnline ISSN 1465-3664
028			_b Phone: +255 28 298 3384
028			_b Fax: +255 28 298 3386
028			_b Email: vc@bugando.ac.tz
028			_b Website: www.bugando.ac.tz
040			_bEnglish _cDLC
041			_aEnglish
100			_aPhilipp Florian Brixius Huth _945746
222			_amalaria, fever, antibiotics, antimalarials, pediatrics
222			_a polymerase chain reaction antimalarials fever malaria tanzania
245			_aExtensive Antibiotic and Antimalarial Prescription Rate among Children with Acute Febrile Diseases in the Lake Victoria Region, Tanzania
260			_aMwanza, Tanzania: _b Oxford University Press & _bCatholic University of Health and Allied Sciences [CUHAS – Bugando] _c2021/2
300			_aPages fmaa135
490			_vJournal of Tropical Pediatrics Volume 67 Issue 1
520			_aAbstract: Objectives: Acute mosquito-borne febrile diseases pose a threat to children in the Sub-Saharan-Africa with ∼272 000 children dying worldwide from malaria in 2018. Although the awareness for malaria in this area has increased due to improved health education, the apparent decline of actual malaria cases has not affected clinical practice significantly. This study collected clinical and epidemiologic data of children presenting with acute febrile diseases in order delineate their diagnostic and therapeutic management. Methods: A hospital-based cross-sectional clinical study was conducted at the Sekou Toure Regional Referral Hospital in Tanzania. Children between 1 month and 12 years of age with an axillary temperature ≥ 37.5°C were recruited from August 2016 to December 2016. Children received full clinical examination. In addition, file data about diagnostics and treatment were collected and malaria rapid diagnostic tests (mRDTs) were performed. Confirmatory malaria polymerase chain reaction was performed from dry blood spots. Results: From 1381 children presented in the pediatric outpatient department, 133 met the inclusion criteria. Out of 133 febrile children, 10.5% were malaria positive. Treatment data indicate the prescription of antimalarials in 35.3% and antibiotics in 63.9% of the children with an overlap of 24.1% receiving both. Despite a negative mRDT, 36 patients received antimalarials. Conclusions: The findings of this study confirm a significant decline of malaria cases in the Lake Victoria region. The discrepancy between the valuable results provided by mRDTs and the high prescription rates of antibiotics and antimalarials call for an enforced diagnostic and therapeutic algorithm.
700			_a Marylyn Addo _945747
700			_a Tim Daniel _945748
700			_a Britta Groendahl _922965
700			_a Adolfine Hokororo _922795
700			_a Philip Koliopoulos _945749
700			_aStephen Mshana _919597
700			_aLeah Pretsch _945750
700			_a Christian Schmidt _945751
700			_aAntke Zuechner _923285
700			_a Stephan Gehring _922969
700			_aNeema Kayange _922515
856			_uhttps://doi.org/10.1093/tropej/fmaa135
942			_2ddc _cVM
999			_c19605 _d19605