| 000 | 03098nam a22003257a 4500 | ||
|---|---|---|---|
| 003 | OSt | ||
| 005 | 20240305193732.0 | ||
| 008 | 221122b |||||||| |||| 00| 0 eng d | ||
| 022 | _aOnline ISSN 1460-2709 | ||
| 028 | _b Phone: +255 28 298 3384 | ||
| 028 | _b Fax: +255 28 298 3386 | ||
| 028 | _b Email: vc@bugando.ac.tz | ||
| 028 | _b Website: www.bugando.ac.tz | ||
| 040 |
_bEngish _cDLC |
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| 041 | _aEnglish | ||
| 100 |
_aMartha F Mushi _919663 |
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| 222 | _aCandida spp, Virulence, Antifungal susceptibiltiy | ||
| 222 | _a antifungal agents endopeptidases phospholipase tanzania virulence peptide hydrolases candida | ||
| 245 | _aVirulence and susceptibility patterns of clinical Candida spp. isolates from a tertiary hospital, Tanzania | ||
| 260 |
_aMwanza, Tanzania: _bOxford University Press & _b Catholic University of Health and Allied Sciences [CUHAS – Bugando] _c 2019/7/1 |
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| 300 | _aPages 566-572 | ||
| 490 | _vMedical mycology Volume 57 Issue 5 | ||
| 520 | _aAbstract: Despite the increased burden of human immunodeficiency virus (HIV) and other comobidities in developing countries, information regarding antifungal susceptibility patterns of Candida spp. and their virulence potential are still limited. Here, we report the virulence and antifungal susceptibility patterns of Candida spp. from varieties spectrum of candidiasis in a tertiary hospital, Tanzania. The study was conducted from March to December 2017. Candida spp. from clinical samples were characterized. Antifungal susceptibility patterns based on EUCAST guidelines and virulence activities (phospholipase, protease, hemolysin, and coagulase activity) were determined. A total of 399 Candida spp. isolates were obtained, of these, 278, 51 and 47 were C. albicans, C. tropicalis, and C. glabrata, respectively. Phospholipase 193/268, protease 32/51 and coagulase 25/47 were the most frequently detected virulence activities in C. albicans, C. tropicalis, and C. glabrata, respectively. Protease and phospholipase were frequently detected virulence activities from C. albicans from blood and esophageal brushes. The median zone diameter of protease activities was significantly larger among C. tropicalis than C. albicans. C. albicans, and C. tropicalis isolates were 100% sensitive to caspofungin. The proportions of C. albicans isolate resistant to fluconazole, voriconazole and posaconazole were 3.1, 3.6%, and 1.8%, respectively. In conclusion, the majority of Candida spp. isolates were sensitive to fluconazole. There are different phenotypes of C. albicans, C. glabrata and C. tropicalis based on susceptibility and virulence activities patterns, necessitating further molecular characterizations to place them in global perspective. Routine antifungal susceptibility testing to guide clinical therapy should be encouraged in developing countries. | ||
| 700 |
_aOliver Bader _923714 |
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| 700 |
_a Christine Bii _945600 |
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| 700 |
_a Uwe Groß _923520 |
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| 700 |
_a Stephen E Mshana _915820 |
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| 856 | _uhttps://doi.org/10.1093/mmy/myy107 | ||
| 942 |
_2ddc _cVM |
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| 999 |
_c19567 _d19567 |
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