000			04867nam a22003137a 4500
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005			20240305193732.0
008			221121b |||||||| |||| 00| 0 eng d
028			_b Phone: +255 28 298 3384
028			_bFax: +255 28 298 3386
028			_b Email: vc@bugando.ac.tz
028			_bWebsite: www.bugando.ac.tz
040			_bEnglish _cDLC
041			_aEnglish
100			_aMariam M Mirambo _922927
245			_aSeropositivity of Brucella spp. and Leptospira spp. antibodies among abattoir workers and meat vendors in the city of Mwanza, Tanzania _bA call for one health approach control strategies
260			_aMwanza, Tanzania: _b Public Library of Science & _b Catholic University of Health and Allied Sciences [CUHAS – Bugando] _cJune 25, 2018
300			_a Pages e0006600
490			_vPLoS neglected tropical diseases Volume 12 Issue 6
520			_aAbstract Introduction: Brucellosis and leptospirosis are among neglected tropical zoonotic diseases particularly in the resource limited countries. Despite being endemic in these countries, there is paucity of information on its magnitude. This study investigated seropositivity of Brucella spp. and Leptospira spp., and associated factors among abattoir workers and meat vendors in the city of Mwanza, Tanzania. Methodology: A community based cross-sectional study was conducted in Mwanza city from May to July 2017. Socio-demographic and other relevant information were collected. Detection of Brucella spp. and Leptospira spp. antibodies were done using slide agglutination test and microscopic agglutination test, respectively. Data were analyzed using STATA version 13 Software. Findings: A total of 250 participants (146 abattoir workers and 104 meat vendors) were enrolled with median age of 31 (IQR: 25–38) years. The overall, seropositivity of Brucella spp. antibodies was 48.4% (95% Cl: 42–54). Seropositivity of B. abortus was significantly higher than that of B. melitensis (46.0%, 95%Cl: 39–52 vs. 23.6%, 95% Cl: 18–28, P<0.001) while seropositivity of both species was 21.2% (95%Cl: 16–26). The seropositivity of Leptospira spp. was 10.0% (95% CI: 6–13) with predominance of Leptospira kirschneri serovar Sokoine which was detected in 7.2% of the participants. Being abattoir worker (OR: 2.19, 95% CI 1.06–4.54, p = 0.035) and long work duration (OR: 1.06, 95%CI: 1.01–1.11, p = 0.014) predicted presence of both B.abortus and B. melitensis antibodies. Only being married (p = 0.041) was significantly associated with seropositivity of Leptospira spp. Primary education was the only factor independently predicted presence of Brucella spp. antibodies among abattoir workers on sub-analysis of occupational exposure. None of factors were found to be associated with presence of Brucella spp. antibodies among meat vendors on sub-analysis. Conclusion: Seropositivity of B.abortus antibodies among abattoir workers and meat vendors is high and seem to be a function of being abattoir worker, having worked for long duration in the abattoir and having primary education. In addition, a significant proportion of abattoir workers and meat vendors in the city was seropositive for Leptospira kirschneri serovar Sokoine. There is a need to consider ‘one health approach’ in devising appropriate strategies to control these diseases in the developing countries. Author summary: Brucellosis and leptospirosis are among neglected diseases in many low-income countries affecting both animals and human populations. Despite being common, the information on their distribution are scarce. In a view of that, this study investigated the proportion of participants with positive antibody test specifically for the two diseases among slaughter house workers and meat sellers in Mwanza city. The study involved 250 participants aged between 25 and 38 years. Overall, 48.4% of participants were Brucella spp. seropositive. Proportion of participants who were positive for B. abortus specific antibodies was higher than that of B. melitensis while 21.2% of them found to have antibodies for both species studied. Furthermore, about 10% of the participants had Leptospira antibodies. Being abattoir worker, long work duration and having primary education were associated with the presence of Brucella antibodies while only being married was associated with the presence of Leptospira antibodies. The findings from this study emphasize the need for multisectoral approach in devising control strategies for these pathogens.
700			_a Georgies F Mgode _945644
700			_a Zakaria O Malima _945645
700			_aMatata John _945646
700			_aElifuraha B Mngumi _945647
700			_aGinethon G Mhamphi _945648
700			_aStephen E Mshana _915820
856			_uhttps://doi.org/10.1371/journal.pntd.0006600
942			_2ddc _cVM
999			_c19549 _d19549