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022			_a2049-3258
027			_q Phone: +255 28 298 3384
027			_q Fax: +255 28 298 3386
027			_q Email: vc@bugando.ac.tz
027			_q Website: www.bugando.ac.tz
040			_cDLC
041			_aEnglish
100			_aMariam M Mirambo _922927
222			_a Anti-HBs HBsAg Anti HBV-core Students Tanzania
245			_aHepatitis B virus infections among health professional students in Mwanza city, Tanzania in 2016
260			_aMwanza, Tanzania: _b BioMed Central & _b Catholic University of Health and Allied Sciences [CUHAS – Bugando] _c18 August 2020
300			_aPages 1-5
490			_vArchives of Public Health Volume 78 Issue 1
520			_aAbstract Background: The World Health Organisation (WHO) recommends the vaccination against Hepatitis B virus in all infants and children up to the age of 18 years. In addition, adults in high-risk groups should also be vaccinated. This study investigated the prevalence and factors associated with Hepatitis B Virus (HBV) infections among health professional students in the city of Mwanza, Tanzania in order to provide data that can assist in devising prevention and control strategies in this special group. Methods: A cross-sectional study involving health professional students of the Catholic University of health and Allied Sciences was conducted between April and July 2016. Hepatitis B surface antigen was detected using rapid antigen test while the anti-hepatitis B surface antibodies(anti-HBs) were quantified using Enzygnost Anti-HBs II assay and anti-HBV core antibodies tested using enzyme immunoassay. Results: A total of 1211 health professional students with median age of 22 interquartile range (IQR):21–24 years were enrolled. The slighlty majority (57.5%) of these students were males and 475(39.2%) were in clinical practices. Out of 1211 students, 37 (3.1%) were Hepatitis B surface antigen positive. Of 1174 students tested for anti-HBs, 258 (22%) had titres > 10 IU/L indicating HBV immunity. The median anti-HBs titres was 47.7 IU/L(IQR:16–3-113). A total of 230(89.2%) students among those who were positive for anti-HBs were also positive for HBV core antibodies indicating HBV natural infections. Male sex (adjusted odd ratio(AOR):1.77, p < 0.000), being married (AOR:1.82, p = 0.002) and being in clinical practices (AOR:1.39, p = 0.028) independenlty predicted anti-HBs positivity. Conclusion: A significant proportion of health professional students was naturally immune to Hepatitis B virus. There is a need to measure anti-HBs in order to reduce the cost of unnecessary vaccination especially in the countries with high endemicity of HBV.
700			_a Emmanuel Mkumbo _945383
700			_a Hadija Selega _945384
700			_a Betrand Msemwa _919669
700			_a Martha F Mushi _919663
700			_a Vitus Silago _919665
700			_a Jeremiah Seni _919633
700			_a Stephen E Mshana _915820
700			_a Christa Kasang _923005
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