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| 003 | OSt | ||
| 005 | 20240305193726.0 | ||
| 008 | 221114b |||||||| |||| 00| 0 eng d | ||
| 022 | _a 1472-6815 | ||
| 028 | _b Phone: +255 28 298 3384 | ||
| 028 | _b Fax: +255 28 298 3386 | ||
| 028 | _b Email: vc@bugando.ac.tz | ||
| 028 | _b Website: www.bugando.ac.tz | ||
| 040 | _cDLC | ||
| 041 | _aEnglish | ||
| 100 |
_aMartha F Mushi _919663 |
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| 222 | _a Methicillin Resistant Staphylococcus Aureus Conductive Hearing Loss Chronic Suppurative Otitis Medium Extended Spectrum Beta Lactamases Tympanic Membrane Perforation | ||
| 245 | _aPredictors of disease complications and treatment outcome among patients with chronic suppurative otitis media attending a tertiary hospital, Mwanza Tanzania | ||
| 260 |
_aMwanza, Tanzania: _b BioMed Central & _b Catholic University of Health and Allied Sciences [CUHAS – Bugando] _c07 January 2016 |
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| 300 | _a Pages 1-8 | ||
| 490 | _vBMC Ear, Nose and Throat Disorders Volume 16 Issue 1 | ||
| 520 | _aAbstract Background: Chronic suppurative otitis media (CSOM) is a major health problem in developing countries causing hearing loss and life threatening complications. Early and effective treatment based on the knowledge of causative micro-organisms and predictors of outcome are crucial in preventing these associated complications. This study was conducted to determine the predictors of CSOM complications, treatment outcome and antimicrobial susceptibility of pathogens, thus providing essential evidence to formulate a policy for management of CSOM. Methods: This was a prospective hospital based cross sectional study involving 301 patients attending Ear Nose and Throat (ENT) clinics at Bugando Medical Centre (BMC) between October 2013 and March 2014. A standardized data collection tool was used to collect demographics and clinical characteristics of patients with CSOM. Ear swabs were collected using sterile cotton swabs and transported to the laboratory for culture and antibiotic susceptibility testing. Results: Out of 301 patients with CSOM; 187 (62.1 %) had positive aerobic culture within 48 h of incubation. Disease complications and poor treatment outcome were observed in 114 (37.8 %, 95 % CI; 32.2–43.3) and 46 (15.3 %, 95 % CI; 11.2–19.3) respectively. On multivariate logistic regression analysis factors found independently to predict both disease complications and poor treatment outcome were otalgia, being infected by multi drug resistant bacteria and being HIV positive. Prolonged illness duration before seeking medical attention was also found to be associated with disease complications (OR 1.029, 95 % CI 1.007–1.05, p = 0.01). A total of 116 (61 %) of gram negative bacteria were isolated. Of 34 Staphylococcus aureus, 14 (41 %) were found to be methicillin resistant Staphylococcus aureus (MRSA) while of 116 g negative enteric bacteria, 49 (42 %) were extended spectrum beta lactamases producers (ESBL). Conclusions: Findings of this study suggest that positive HIV status, infection due to multidrug resistant pathogens and otalgia are significantly associated with disease complications and poor treatment outcome. Of great importance this study confirms that prolonged illness duration without seeking medical attention significantly predicts disease complications. Urgent preventive measures and laboratory guided early treatment are necessary to reduce complications associated with CSOM. | ||
| 700 |
_aAlfred E Mwalutende _922947 |
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| 700 |
_aJaphet M Gilyoma _922731 |
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| 700 |
_a Phillipo L Chalya _915821 |
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| 700 |
_a Jeremiah Seni _919633 |
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| 700 |
_a Mariam M Mirambo _922927 |
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| 700 |
_a Stephen E Mshana _915820 |
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| 856 | _uhttps://doi.org/10.1186/s12901-015-0021-1 | ||
| 942 |
_2ddc _cVM |
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| 999 |
_c19414 _d19414 |
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