000			02567nam a22002777a 4500
003			OSt
005			20240305193725.0
008			221110b |||||||| |||| 00| 0 eng d
028			_b Phone: +255 28 298 3384
028			_b Fax: +255 28 298 3386
028			_b Email: vc@bugando.ac.tz
028			_b Website: www.bugando.ac.tz
040			_cDLC
041			_aEnglish
100			_aD Gunda _945261
245			_aPrevalence and Predictors of Virological Failure among Adults HIV Patients Receiving First Line ART in Northwestern Tanzania _b A Cross Sectional Study
260			_aMwanza: _b Tanzania Catholic University of Health and Allied Sciences [CUHAS – Bugando] _c2020/9/7
300			_a Pages 683-90
490			_v EC Microbiology Volume 15 Issue 9
520			_aBackground: Prevalence of immunological failure has been shown to be high in some African countries. Few studies however have assessed the magnitude of virological failure in Tanzania. This study aimed at determining virological failure and its associated factors in north western Tanzania. Methods: A cross sectional study was conducted among HIV-infected patients who were receiving first line ART at Bugando medical centre. Virological loads were measured and socio-demographic and clinical information were collected for analysis. Patients with a single viral load of> 10,000 copies/ml were coded as having virological failure as per WHO definition and poor adherence level was defined as any adherence level of< 95%. Data analysis was done using STATA 11 to determine the proportion of patients with virological failure and its associated factors. Results: In total 274 patients were enrolled and, 43 (15.7%) met the criteria of virological failure. The odds of having virological failure were independently associated with baseline CD4 counts of< 200 cells/µl (AOR= 8.6 (1.7-42.1), p= 0.008), poor adherence (AOR= 15.4 (6.6-36.1), p< 0.0001) and Nevirapine based regimen (AOR= 4.1 (1.6-10.4), p= 0.003). Conclusion: Virological failure is prevalent among HIV patients on first line ART. Test and treat, adherence counseling and regular virological monitoring could optimize the virological outcome of HIV patients receiving first line ART in Tanzania and similar setting.
700			_a S Kilonzo _945262
700			_aE Kamugisha _923593
700			_aJ Meda, B Mpondo _945263
856			_uhttps://scholar.google.com/citations?view_op=view_citation&hl=en&user=yZAiL9MAAAAJ&cstart=20&pagesize=80&citation_for_view=yZAiL9MAAAAJ:bEWYMUwI8FkC
942			_2ddc _cVM
999			_c19380 _d19380