| 000 | 02535nam a22002657a 4500 | ||
|---|---|---|---|
| 003 | OSt | ||
| 005 | 20240305193725.0 | ||
| 008 | 221110b |||||||| |||| 00| 0 eng d | ||
| 028 | _b Phone: +255 28 298 3384 | ||
| 028 | _b Fax: +255 28 298 3386 | ||
| 028 | _b Email: vc@bugando.ac.tz | ||
| 028 | _b Website: www.bugando.ac.tz | ||
| 040 | _cDLC | ||
| 041 | _aEnglish | ||
| 100 |
_aSemvua B Kilonzo _922704 |
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| 245 |
_aLiver fibrosis and hepatitis B coinfection among ART naive HIV-infected patients at a tertiary level hospital in northwestern Tanzania _ba cross-sectional study |
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| 260 |
_aMwanza: _b Hindawi & _b Tanzania Catholic University of Health and Allied Sciences [CUHAS – Bugando] _c30 Jul 2017 |
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| 490 | _vJournal of tropical medicine Volume 2017 | ||
| 520 | _aAbstract Background: Liver fibrosis which is a common complication of chronic hepatitis B infection is rarely diagnosed in low-resource countries due to limited capacity to perform biopsy studies. Data on the utilization of noninvasive techniques which are feasible for diagnosis of liver fibrosis in these settings among HIV-infected patients is scarce. The objective of this study was to establish the magnitude of liver fibrosis by using both aspartate-aminotransferase-to-platelets ratio and fibrosis-4 scores with associated hepatitis B coinfection among antiretroviral therapy naïve HIV-infected patients. Methods: We reviewed data of 743 adult patients attending HIV clinic with available hepatitis B surface antigen test results. Baseline clinical information was recorded and aspartate-aminotransferase-to-platelet ratio and fibrosis-4 scores were calculated. The cut-off values of 1.5 and 3.25 were used for diagnosis of significant fibrosis by aspartate-aminotransferase-to-platelets ratio and fibrosis-4 scores, respectively. Results: The prevalence of liver fibrosis was 3.5% when aspartate-aminotransferase-to-platelet score was used and 4.6% with fibrosis-4 score and they were both significantly higher among patients with hepatitis B coinfection. Younger patients with HIV advanced disease and elevated liver transaminases had increased risk of having hepatitis B coinfection. Conclusion: A remarkable number of HIV-infected patients present with liver fibrosis, predominantly those with hepatitis B infection. | ||
| 700 |
_a Daniel W Gunda _922748 |
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| 700 |
_aFlora Kashasha _945245 |
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| 700 |
_a Bonaventura C Mpondo _945243 |
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| 856 | _uhttps://doi.org/10.1155/2017/5629130 | ||
| 942 |
_2ddc _cVM |
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| 999 |
_c19369 _d19369 |
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