000			03235nam a22003257a 4500
003			OSt
005			20240305193724.0
008			221110b |||||||| |||| 00| 0 eng d
028			_b Phone: +255 28 298 3384
028			_b Fax: +255 28 298 3386
028			_b Email: vc@bugando.ac.tz
028			_b Website: www.bugando.ac.tz
040			_cDLC
041			_aEnglish
100			_aDaniel W Gunda [RIP] _922943
222			_aEndoscopy, esophageal candidiasis, HIV
245			_aPrediction of Esophageal Candidiasis among Newly Diagnosed People Living with HIV at a Tertiary Hospital in Northwestern Tanzania _bA Cross Sectional Study
260			_aMwanza: _bTanzania Medical Journal & _b Tanzania Catholic University of Health and Allied Sciences [CUHAS – Bugando] _c2022/1/31
300			_aPages 1-15
490			_vTanzania Medical Journal Volume 33 Issue 1
520			_a Abstract Background: HIV infection causes a multisystem disease. Patients with upper gastrointestinal symptoms like dyspepsia, odynophagia, and dysphagia sometimes are usually treated empirically for esophageal candidiasis. Studies have suggested that a variety of other conditions may present with upper GIT and thus empirical treatment could potentially delay the institution of definitive treatment. This study describes endoscopic findings and prediction of esophageal candidiasis, which is an AIDS-defining illness among newly diagnosed people living with HIV at the Gastroenterology and hepatology unit at Bugando Tanzania. Methods: A cross-section study was carried out among adult patients who presented at gastroenterology and hepatology unit for endoscopic service. All patients underwent HIV testing and counseling before the endoscope. Those who tested positive for HIV were serially enrolled in this study. Demographic, symptom profile, CD4 counts, and endoscopic findings were analyzed using STATA 13. The odds ratio (OR) with 95% Confidence Interval (CI) was calculated using univariate analysis followed by a multivariate analysis model to assess the extent of association. P value of <0.05 was considered as significant. Results: In total 210 patients were enrolled in this study. The top three endoscopic findings were gastritis, 70 (33.3%; 95%CI: 26.9-39.7), esophageal candidiasis, 63 (30.0%; 95%CI: 23.8-36.2) and esophageal carcinoma, 28 (13.3%; 95%CI: 8.6-17.9). The presence of esophageal candidiasis was independently associated with Odynophagia, (OR: 6.1; 95%CI: 2.1-17.7; p=0.001), upper abdominal pain (OR: 2.3; 95%CI: 1.0-5.1, p=0.045) and CD4 count of less than 200cells/µL, (OR: 2.7; 95%CI: 1.3-5.3; p=0.005). Conclusion: Esophageal candidiasis is prevalent in this study. Though Odynophagia, epigastric pains, and low CD4 counts can predict the presence of esophageal candidiasis, endoscopy is indicated for precise diagnosis of other conditions including esophageal carcinoma.
700			_a Humphrey D Mazigo _922835
700			_aDerek M Sharau _945199
700			_aPaulina M Manyiri _922925
700			_a David C Majinge _922926
700			_aSamwel E Kalluvya _945200
700			_aSemvua B Kilonzo _922704
856			_uhttps://doi.org/10.4314/tmj.v33i1.413
942			_2ddc _cVM
999			_c19345 _d19345