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028			_b Phone: +255 28 298 3384
028			_bFax: +255 28 298 3386
028			_b Email: vc@bugando.ac.tz
028			_b Website: www.bugando.ac.tz
040			_cDLC
041			_aEnglish
100			_aMwanaisha Seugendo _923365
222			_aClostridium difficile diarrhoea immunocompromised sub-Saharan Tanzania
245			_aClostridium difficile infections among adults and children in Mwanza/Tanzania: is it an underappreciated pathogen among immunocompromised patients in sub-Saharan Africa?
260			_aMwanza: _b Elsevier & _bTanzania Catholic University of Health and Allied Sciences [CUHAS – Bugando] _cNovember 2015
300			_a Pages 99-102
490			_vJournal New microbes and new infections Volume 8
520			_aAbstract Little is known regarding the epidemiology Clostridium difficile in developing countries. Fresh stool samples from patients with diarrhoea were cultured anaerobically. C. difficile was detected in nine (6.4%) of 141 (95% confidence interval 4.2–13.1), of which seven (77.8%) were from children. HIV infection, prolonged hospitalization and antibiotic use were independent factors associated with the occurrence of C. difficile in the gastrointestinal tract. Two of the toxigenic isolates were typed as ribotype 045, and the other two had unknown ribotype. All C. difficile isolates were susceptible to metronidazole, moxifloxacin and clarithromycin, while three isolates were resistant to clarithromycin. C. difficile may be an important pathogen causing diarrhoea in sub-Saharan Africa among immunocompromised patients.
700			_aStephen E Mshana _915820
700			_aAldofineh Hokororo _923224
700			_aBenard Okamo _923574
700			_aMariam M Mirambo _922927
700			_a Lutz von Müller _923575
700			_aKatrin Gunka _923577
700			_aOrtrud Zimmermann _923569
700			_a Uwe Groß _923520
856			_uhttps://doi.org/10.1016/j.nmni.2015.09.016
942			_2ddc _cVM
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