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022			_aeISSN: 1026-552X
028			_b Phone: +255 28 298 3384
028			_b Fax: +255 28 298 3386
028			_b Email: vc@bugando.ac.tz
028			_b Website: www.bugando.ac.tz
040			_cDLC
041			_aEnglish
100			_aVicky P Manyanga _944998
222			_aHPTLC, method validation, assay, mebendazole
245			_aA High-performance Thin Layer Chromatography Densitometric Method for the assay of Mebendazole Tablets
260			_aMwanza: _b Tanzania Catholic University of Health and Allied Sciences [CUHAS – Bugando] & _b East and Central African Journal of Pharmaceutical Sciences _c2020-10-01
300			_aPages 54-59
490			_vJournal East and Central African Journal of Pharmaceutical Sciences Volume 23 Issue 2
520			_aAbstract A simple, precise and accurate high-performance thin layer chromatographic (HPTLC) method was developed for the assay of mebendazole tablets. The separation was carried out by using HPTLC Silica gel 60 F254, (20 × 10 cm) with 250 μm thickness using ethyl acetate - ammonia 25% solution (25:0.5) as a mobile phase. HPTLC separation of the drug was followed by densitometry measurement at 310 nm. Mebendazole was satisfactorily resolved with retention factor (Rf) values of 0.51 ± 0.02. The method complied with International Conference on Harmonization acceptance criteria for linearity (250 - 600 ng), precision, accuracy and specificity.
700			_a Emmanuel Kimaro _926657
700			_aJoseph Sempombe _944999
700			_aEliangiringa Kaale _944997
700			_aMhina Chambuso _945000
942			_2ddc _cVM
999			_c19238 _d19238