000			02897nam a22003497a 4500
003			OSt
005			20240305193719.0
008			221101b |||||||| |||| 00| 0 eng d
028			_b Phone: +255 28 298 3384
028			_b Fax: +255 28 298 3386
028			_b Email: vc@bugando.ac.tz
028			_bWebsite: www.bugando.ac.tz
040			_cDLC
041			_aEnglish
100			_aPatrizia Serra _944781
245			_aEvaluating the appropriateness of chemotherapy in a low‐resource cancer centre in sub‐Saharan Africa
260			_aMwanza: _bJohn Wiley & Sons, Inc. & _bTanzania Catholic University of Health and Allied Sciences [CUHAS – Bugando] _c13 November 2019
300			_aPages 133-140
490			_vJournal Cancer medicine Volume 9 Issue 1
520			_a Abstract Background To evaluate the appropriateness of chemotherapy use at the Oncology Department of the Bugando Medical Centre of Mwanza, Tanzania. Methods The study was an observational prevalence-based study designed to evaluate a single-chemotherapy cycle during a defined time period for a cross-section of patients at varying stages of their clinical history. The sample included 103 consecutive subjects who were treated during January-March 2017 and had at least one previous cycle. Chemotherapy treatment omissions, cycle delays, and dose reductions and their causes were recorded using a standard form that included demographic, anthropometric, and clinical items. The data were analyzed descriptively. Results There were 59 males (57.3%) and 44 females (42.7%). Ninety-four patients were aged ≥18 years. Considering cancer type/site, there were 23 distinct groups of patients. The recorded number of drugs in the chemotherapy regimens varied between one and five. The median cycle number was three (range: 2-11). Sixty-eight (66.0%) patients were treated in a standard fashion. For the remaining, cycle delay and dose reduction were the most common cause for nonstandard treatment. Hematologic toxicity was responsible for the greater part of cycle delays, whereas dose reductions were accounted for by a larger spectrum of causes. Overall, toxicity explained 21/35 (60.0%) patients receiving nonstandard treatment. The distribution of toxic events was skewed toward grade 1 and grade 2. Conclusions The observed level of appropriateness of chemotherapy was encouraging. The proportion of patients experiencing severe toxic effects was lower than expected.
700			_aDeogratias M Katabalo _944838
700			_aNestory Masalu _922884
700			_a Dino Amadori _944945
700			_a Salustia Bugingo _944958
700			_aFlavia Foca _944959
700			_aSara Bravaccini _944782
700			_aCaterina Donati _944960
700			_a Lauro Bucchi _944961
700			_a Carla Masini _944962
856			_u https://doi.org/10.1002/cam4.2672
942			_2ddc _cVM
999			_c19232 _d19232