000			03108nam a22003377a 4500
003			OSt
005			20240305193716.0
008			221011b |||||||| |||| 00| 0 eng d
022			_aeISSN: 1821-9241
022			_a print ISSN: 1821-6404
028			_bPhone: +255 28 298 3384
028			_bFax: +255 28 298 3386
028			_bEmail: vc@bugando.ac.tz
028			_b Website: www.bugando.ac.tz
040			_cDLC
041			_aEnglish
100			_aSE Mshana _923705
222			_a prevalence, clindamycin, methicillin-resistant, Staphylococcus aureus, Tanzania
245			_aPrevalence of clindamycin inducible resistance among methicillin-resistant Staphylococcus aureus at Bugando Medical Centre, Mwanza, Tanzania
260			_aMwanza, Tanzania: _bTanzania Journal of Health Research & _bCatholic University of Health and Allied Sciences [CUHAS – Bugando] _c2009
490			_vTanzania Journal of Health Research Volume 11 Issue 2
520			_aAbstract Abstract: Methicillin-resistant Staphylococcus aureus (MRSA) has been recognized world wide as an important causative agent of nosocomial and community acquired infections. Clindamycin has been considered as an alternative drug for the treatment of such strains. However, the possibility of clindamycin inducible resistance complicates the choice of treatment. The aim of this study was to determine the prevalence of clindamycin inducible resistance of MRSA at Bugando Medical Centre (BMC) in Mwanza Tanzania. A total of 600 clinical specimens of pus, wound swabs and aspirates from patients admitted at BMC surgical wards were processed over a period of 4 months. Of these, 160 of S. aureus clinical isolates were analysed. MRSA was identified using cefoxitin disc, oxacillin disc and oxacillin agar. Inducible clindamycin resistance was detected using erythromycin (15μg) and clindamycin (2μg) discs placed 15mm apart on Muller Hinton agar. Of the 160 isolates, 26 (16.3%) were found to be MRSA. Overall prevalence of inducible clindamycin resistance (iMLSB) was 28.8% (46/160), with 22% (30/134) of methicillin-susceptible S. aureus (MSSA) and 61% (16/26) of MRSA exhibiting inducible clindamycin resistance (P=0.0001). Constitutive resistance (cMLSB) was found in 1 (3.7%) of the MRSA isolates and was not detected among MSSA. MSB phenotype was detected in 1 (3.8%) of MRSA isolates and 2 (1.5%) of MSSA. Eight (29.6%) of the MRSA isolates were sensitive to both clindamycin and erythromycin. In conclusion, a high prevalence of inducible clindamycin resistance was observed among S. aureus with significant association between MRSA and inducible clindamycin resistance. It is important that susceptibility test of staphylococci is routinely done to facilitate early detection of clindamycin inducible resistance in the country.
700			_a E Kamugisha _923593
700			_aM Mirambo _923597
700			_a P Chalya _944625
700			_aP Rambau _923596
700			_a W Mahalu _944626
700			_aE Lyamuya _944627
856			_y https://doi.org/10.4314/thrb.v11i2.45197
942			_2ddc _cVM
999			_c19134 _d19134