000 | 03121nam a22003137a 4500 | ||
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008 | 210826b |||||||| |||| 00| 0 eng d | ||
022 | _a2047-2994 | ||
100 |
_a David Patrick Kateete _923720 |
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222 | _a Eastern Uganda; Iganga/Mayuge districts; Coexistence; Hospital-associated MRSA; Community-associated MRSA; mecA; SCCmec types; spa types | ||
245 | _a CA-MRSA and HA-MRSA coexist in community and hospital settings in Uganda | ||
260 |
_aMwanza, Tanzania: _bCatholic University of Health and Allied Sciences CUHAS - Bugando & _b BioMed Central _c 03 June 2019 |
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300 | _a Pages 1-9 | ||
490 | _vAntimicrobial Resistance & Infection Control Volume 8 Issue 1 | ||
520 | _aAbstract Background: Methicillin resistant Staphylococcus aureus (MRSA) strains were once confined to hospitals however, in the last 20 years MRSA infections have emerged in the community in people with no prior exposure to hospitals. Strains causing such infections were novel and referred to as community-associated MRSA (CA-MRSA). The aim of this study was to determine the MRSA carriage rate in children in eastern Uganda, and to investigate coexistence between CA-MRSA and hospital-associated (HA-MRSA). Methods: Between February and October 2011, nasopharyngeal samples (one per child) from 742 healthy children under 5 years in rural eastern Uganda were processed for isolation of MRSA, which was identified based on inhibition zone diameter of ≤19 mm on 30 μg cefoxitin disk. SCCmec and spa typing were performed for MRSA isolates. Results: A total of 140 S. aureus isolates (18.9%, 140/742) were recovered from the children of which 5.7% (42/742) were MRSA. Almost all (95.2%, 40/42) MRSA isolates were multidrug resistant (MDR). The most prevalent SCCmec elements were types IV (40.5%, 17/42) and I (38.1%, 16/42). The overall frequency of SCCmec types IV and V combined, hence CA-MRSA, was 50% (21/42). Likewise, the overall frequency of SCCmec types I, II and III combined, hence HA-MRSA, was 50% (21/42). Spa types t002, t037, t064, t4353 and t12939 were detected and the most frequent were t064 (19%, 8/42) and t037 (12%, 5/42). Conclusion: The MRSA carriage rate in children in eastern Uganda is high (5.7%) and comparable to estimates for Mulago Hospital in Kampala city. Importantly, HA-MRSA (mainly of spa type t037) and CA-MRSA (mainly of spa type t064) coexist in children in the community in eastern Uganda, and due to high proportion of MDR detected, outpatient treatment of MRSA infection in eastern Uganda might be difficult. | ||
700 |
_aMoses L. Joloba _923380 |
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700 |
_a Benon B. Asiimwe _923721 |
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700 |
_a Elizeus Rutebemberwa _923722 |
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700 |
_aKarin Källander _923723 |
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700 |
_a Christine F. Najjuka _923377 |
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700 |
_aHannington Baluku _923724 |
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700 |
_aFred K. Ashaba _923725 |
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700 |
_aBrian Mujuni _923726 |
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700 |
_aEdgar Kigozi _923727 |
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700 |
_aRaymond Mayanja _923728 |
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700 |
_aJeremiah Seni _919633 |
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700 |
_a Freddie Bwanga _923376 |
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856 | _uhttps://doi.org/10.1186/s13756-019-0551-1 | ||
942 |
_2ddc _cVM |
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999 |
_c19025 _d19025 |