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100			_aHamza Saidi _923697
245			_aComplications of sickle cell anaemia in children in Northwestern Tanzania
260			_aMwanza, Tanzania _bCatholic University of Health and Allied Sciences CUHAS - Bugando _c17 Feb 2016
490			_3Hematology Volume 21, 2016 - Issue 4 _aHematology Volume 21, 2016 - Issue 4
520			_aAbstract Objectives: Tanzania has the third highest birth rate of sickle cell anaemia (SCA) in Africa, but few studies describe severity of complications or available treatments, especially in Northwest Tanzania around Lake Victoria where the sickle gene is most prevalent. This is a report of the spectrum of clinical disease and range of interventions available at Bugando Medical Centre (Bugando) in Northwest Tanzania in Africa. Methods: A cross-sectional study was carried out in Bugando between 1 August 2012 and 30 September 2012. Children (<15 years old) with SCA attending Bugando were sequentially enrolled. A trained research assistant completed a Swahili questionnaire with the parent or guardian of each participant concerning demographic information, clinical features of disease, and treatments received. Results: Among the 124 participants enrolled, the median age was 6 years (interquartile range [IQR] 4–8.5), and only 13 (10.5%) were < 3 years old. Almost all participants (97.6%) had a prior history of a vaso-occlusive episode, 83 (66.9%) had prior acute chest syndrome, and 21 (16.9%) had prior stroke. In the preceding 12 months, 120 (96.8%) had been hospitalized, and a vaso-occlusive episode was the most common reason for hospitalization (35.5%). Prescriptions for folic acid (92.7%) and malaria prophylaxis (84.7%) were common, but only one had received a pneumococcal vaccine, and none had received hydroxyurea or prophylactic penicillin. Conclusion: Children with SCA receiving care in Tanzania are diagnosed late, hospitalized frequently, and have severe complications. Opportunities exist to improve care through wider access to screening and diagnosis as well as better coordination of comprehensive care. Keywords: Sickle cell anaemia Tanzania Sub-Saharan Africa Vaso-occlusive episode Acute chest syndrome Stroke Children
700			_a Luke R. Smart _923177
700			_aErasmus Kamugisha _922814
700			_aEmmanuela E. Ambrose _922852
700			_a Deogratias Soka _923698
700			_aRobert N. Peck _922982
856			_3https://doi.org/10.1080/10245332.2015.1101976
942			_2ddc _cVM
999			_c19017 _d19017