000			02887nam a22002657a 4500
008			210825b |||||||| |||| 00| 0 eng d
022			_a1756-0500
100			_a Edwin Nelson _923620
222			_a ESBL; Post-delivery women; Neonates; Tanzania
245			_aEvaluation of existence and transmission of extended spectrum beta lactamase producing bacteria from post-delivery women to neonates at Bugando Medical Center, Mwanza-Tanzania
260			_aMwanza, Tanzania _b Catholic University of Health and Allied Sciences CUHAS - Bugando & _bBioMed Central _c 03 May 2014
300			_aPages 1-6
490			_vBMC research notes Volume 7 Issue 1
520			_aAbstract Background: Extended spectrum beta-lactamase producing bacteria (ESBL) are common causes of neonatal sepsis worldwide. Neonatal sepsis due to ESBL is associated with increased morbidity and mortality at Bugando Medical Centre (BMC). Due to limited information on the sources of these ESBL strains at BMC, this study was conducted to evaluate the existence, magnitude and transmission of ESBL from post-delivery women to neonates at BMC, Mwanza-Tanzania. Results: A cross-sectional study was conducted at obstetrics and neonatal wards from May to July 2013, involving post-delivery women and their neonates. Rectal swabs were collected and processed to identify the ESBL strains and their antimicrobial susceptibility patterns. Patients’ data were obtained using a standardized data collection tool. We enrolled 113 women and 126 neonates with mean age of 26.5 ± 5.5 years and median gestation age [IQR] of 39 [35–40] weeks respectively. The prevalence of ESBL carriage among women and neonates were 15% (17/113) and 25.4% (32/126) respectively. The acquisition of ESBL isolates among neonates on day 1, day 3 and day 7 were 60.0% (21/35), 25.7% (9/35) and 14.3% (5/35) respectively. There was no phenotypic similarity between ESBL strains from women and their respective neonates, suggesting other sources of transmission. Neonates given antibiotics were more likely to carry ESBL than those not given [100% (32/32) versus 86% (81/94), p = 0.018]. Conclusion: The carriage rate of ESBL strains among post-delivery women and neonates at BMC is high. Our findings suggest that neonates acquire these strains from sources other than post-delivery women and more than half acquire them on the first day of life. More studies are recommended to further explore the sources of ESBL strains among neonates.
700			_aStephen E Mshana _915820
700			_aAlbert Kihunrwa _922809
700			_a Juma Kayega _923621
700			_a Jeremiah Seni _919633
700			_aMartha F Mushi _919663
700			_aBenson R Kidenya _922909
700			_aAdolfine Hokororo _922795
700			_aAntke Zuechner _923285
856			_uhttps://doi.org/10.1186/1756-0500-7-279
942			_2ddc _cVM
999			_c19004 _d19004