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100			_aMariam M.Mirambo _922927
245			_aAdverse pregnancy outcomes among pregnant women with acute Rubella infections in Mwanza city, Tanzania
260			_aMwanza, Tanzania: _b Catholic University of Health and Allied Sciences CUHAS - Bugando & _bElsevier _c2019/1/1
300			_a Pages 72-77
490			_vInternational Journal of Infectious Diseases Volume 78
520			_aAbstract: Objective: This study investigated the adverse pregnancy outcomes among pregnant women with acute Rubella infections in the city of Mwanza, Tanzania. Methods: A longitudinal study was conducted between 2014 and 2016 among pregnant women attending antenatal clinics. Women were screened for Rubella IgG and IgM antibodies using enzyme immunoassay (EIA). IgM seropositive pregnant women were followed up until the end of the pregnancy to determine Congenital Rubella Syndrome, congenital infections and other pregnancy outcomes. Results: The median age of 685 enrolled pregnant women was 23 (IQR: 19–27) years. A total of 629(91.8%) were Rubella IgG seropositive while 61 (8.9%) were IgM seropositive. The IgM seropositivity was found to decrease significantly from first trimester to third trimester, p < 0.001. Forty six (83.6%) of 55 Rubella IgM seropositive women had adverse pregnancy outcomes and 6 (10.9%) delivered neonates with CRS, making the overall incidence of CRS to be 6/685 (0.87%). First trimester IgM seropositive women had significantly higher adverse pregnancy outcomes than those in second/third trimesters (70.4% vs. 35.7, p = 0.01). Conclusion: There is one case of CRS in every 100 pregnancies necessitating additional strategies to reach a goal of elimination of CRS in developing countries.
700			_aSaid Aboud _923519
700			_a Mtebe Majigo _922970
700			_aUwe Groβ _923540
700			_a Stephen E.Mshana _915820
856			_uhttps://doi.org/10.1016/j.ijid.2018.10.020
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