| 000 | 02986nam a22002297a 4500 | ||
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| 008 | 210825b |||||||| |||| 00| 0 eng d | ||
| 100 |
_a Mariam M. Mirambo _922927 |
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| 222 | _a Rubella; IgM; Under-fives; Mwanza; Tanzania; Congenital rubella syndrome | ||
| 245 |
_aSerological evidence of acute rubella infection among under-fives in Mwanza _b a threat to increasing rates of congenital rubella syndrome in Tanzania |
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_aMwanza, Tanzania _bCatholic University of Health and Allied Sciences CUHAS - Bugando & _b BioMed Central _c 25 May 2016 |
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| 300 | _aPages 1-5 | ||
| 490 |
_3 Italian Journal of Pediatrics volume 42, Article number: 54 (2016) _a Italian Journal of Pediatrics volume 42, Article number: 54 (2016) _vItalian Journal of Pediatrics Volume 42 Issue 1 |
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| 520 | _aAbstract Background: Control of rubella infection is essential for preventing congenital rubella syndrome (CRS) and one of the important steps is to define a target population for vaccination. Therefore this study was done to determine serological evidence of acute rubella infection among under-fives in order to anticipate the magnitude of rubella virus transmission in Tanzania. Methods: A cross-sectional study involving children aged between 1 and 59 months was conducted between September and October 2014 before national rubella vaccination campaigns commenced. Rubella IgM antibodies were detected using commercial indirect enzyme-linked immunosorbent assay (ELISA). Data were analyzed using STATA version 11. Results: A total of230 under-fives were enrolled, their median age was 14 (Interquartile range (IQR) 7–26) months. The overall seroprevalence of rubella IgM antibodies was 10.9 % (25/230) with two confirmed cases of CRS. Two-sample Wilcoxon rank-sum test showed that the median age of rubella IgM seropositive children was significantly higher than that of IgM seronegative children (39 IQR: 18-51months vs. 14 IQR: 7–24 months, P < 0.001). On multivariate logistic regression analysis increase in age (OR: 1.07, 95 % CI; 1.03–1.1, P < 0.001) and residing in rural areas (OR: 8.07, 95 % CI; 1.43–45.6, P = 0.018) were independently found to predict acute rubella infection among under-fives. Conclusion: Our findings indicate that rubella virus is prevalent in our setting posing a risk of transmitting to childbearing aged women hence increasing the risk of CRS. Increasing prevalence of acute infection with age in under-fives indicates the protective role of maternal antibodies among infants. The sustained vaccination programme of under-fives as effective measure to control CRS should be emphasized in developing countries. | ||
| 700 |
_a Said Aboud _923519 |
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| 700 |
_aMartha F. Mushi _919663 |
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| 700 |
_aMwanaisha Seugendo _923365 |
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| 700 |
_a Mtebe Majigo _922970 |
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| 700 |
_a Uwe Groß _923520 |
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| 700 |
_a Stephen E. Mshana _915820 |
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| 856 | _uhttps://doi.org/10.1186/s13052-016-0264-5 | ||
| 942 |
_2ddc _cVM |
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| 999 |
_c18970 _d18970 |
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