000			03335nam a22003137a 4500
001			CUHAS/MMED/6000316/T/19
003			CUHAS/MMED/6000316/T/19
005			20240423132414.0
008			221208b |||||||| |||| 00| 0 eng d
028			_bWurzburg Road 35, BMC Premises, Post Code: 33102:
028			_b P. O Box 1464, Mwanza – Tanzania:
028			_bPhone: +255 28 298 3384:
028			_bFax: +255 28 298 3386:
028			_bEmail: vc@bugando.ac.tz :
028			_bWebsite: www.bugando.ac.tz
040			_bEnglish _cddc
041			_aEnglish
100			_aFatma Mrisho Haji _d[Female] _947110 _eCUHAS/MMED/6000316/T/19
222			_aKeywords: _bPlacental Doppler ultrasound, Cerebro-placental ratio, obstetrics risk or conditions, perinatal outcomes.
245			_aDoppler velocimetry in diagnosis of placenta insufficiency and its association to perinatal outcome at Bugando Medical Centre, Mwanza, Tanzania
260			_aMwanza, Tanzania: _b Catholic University of Health and Allied Sciences [CUHAS – Bugando] : _c2022
300			_a85 Pages
300			_aIncludes References and Appendices
520			_aAbstract: Background: Doppler velocimetry of the fetal umbilical, middle cerebral artery and its cerebroplacental ratio (CPR is a non-invasive evaluation tool of fetal wellbeing. Variation of Doppler indices above or below normal limit with certain changes of the normal Doppler waveform pattern can be used as a marker in the diagnosis of placenta insufficiency and possible prediction of perinatal outcomes. Objective: To determine the prevalence of abnormal placenta Doppler, associated risk factors (obstetrics risk), and its association to perinatal outcome. Methods: A longitudinal study was conducted at Bugando Medical Centre in Tanzania over a period of six months. A 393 gravid patients from 28 weeks of gestation age were recruited. Doppler ultrasound evaluation of umbilical and Middle cerebral arteries was performed and CPR was calculated. Newborn assessment was done 24 hours after delivery to determine perinatal outcomes. Collected data was analysed using STATA software version 13. Results: Among 393 recruited participants, prevalence of abnormal placental Doppler was 17.05%. In clinical categorization; the prevalence was higher 61.7% in high-risk pregnancy compared to 1.4% in low-risk group. Hypertensive disorder of pregnancy (OR 32.4; 95% CI [12.2-86.4]; p-value<0.001), PROM (OR 22; 95% CI [5.9-80.0]; p-value < 0.001), diagnosis of unspecified insufficient (OR 18.3; 95% CI [3.8-87.2]; p-value <0.001) and APH (OR 9.9; 95% CI [1.9-50]; p-value 0.006)), were significantly associated with abnormal placenta Doppler study, Abnormal CPR was significant associated with adverse perinatal outcomes. Conclusion: Prevalence of abnormal placenta Doppler (CPR) was high in our setup, based on clinical categorization it become a potentially screening tool to be done in detection of abnormal placental blood flow, in high risk pregnancies. It association with poor peri-natal outcomes as seen in this study, makes it among investigation of choice in identifying fetus with intrauterine complication.
600			_xObstetrics & Gynaecology _947091
700			_aRichard Kirita _922929
700			_aMagreth Magambo _948499
942			_2ddc _cMP
999			_c18568 _d18568