000			03728nam a22003257a 4500
001			CUHAS/MPH/6000250/T/20
003			CUHAS/MPH/6000250/T/20
005			20240423161955.0
008			221208b |||||||| |||| 00| 0 eng d
028			_bWurzburg Road 35, BMC Premises, Post Code: 33102:
028			_b P. O Box 1464, Mwanza – Tanzania:
028			_bPhone: +255 28 298 3384:
028			_b Fax: +255 28 298 3386
028			_b Email: vc@bugando.ac.tz
028			_b Website: www.bugando.ac.tz
035			_aCUHAS/MPH/6000250/T/20
040			_bEnglish _cddc
041			_aEnglish
100			_aSylivester Yasinta D _d[Female] _947105 _eCUHAS/MPH/6000250/T/20
222			_aKeywords: _bEfficacy, hybridization, Introgression background, Schistosomiasis, S. bovis, S. haematobium, praziquantel, Tanzania.
245			_aMolecular identification of Schistosoma haematobium and Schistosoma bovis hybrid species isolated from primary school children and their susceptibility to Praziquantel treatment in Shinyanga District, North-west Tanzania
260			_aMwanza, Tanzania: _bCatholic University of Health and Allied Sciences [CUHAS – Bugando] : _c2022
300			_axv: 97 Pages
300			_aIncludes References and Appendices
520			_aAbstract: Background: Schistosomiasis is a water-borne parasitic disease with the highest socioeconomic impact after Malaria. Preventive chemotherapy using praziquantel has been used as the main intervention in endemic countries, including Tanzania. Recently, studies in West Africa reported that the occurrence of schistostosoma hybrid species among human of up to 36% is one of the factors suspected affected the efficacy of treatment. This study assessed the occurrence of Schistosoma haematobium x Schistosoma bovis hybrids and their effect on praziquantel treatment outcomes in Shinyanga and Misungwi districts, Northwestern Tanzania. Methods: A population-based cross-sectional study was conducted. Urine samples were examined for S. haematobium using the urine filtration method. The occurrence of bovis x S. haematobium hybrids in the studied population was determined using Rapid Diagnostic Multiplex PCR. Results: Out of 1.190 individuals examined, 123 (6.4%) were infected with schistosomma haematobium the prevalence decreased to 6 (0.3%) after the treatment. Males were significantly more infected with urogenital schistosomiasis than females (P <0.001). The prevalence of S. haematobium was significantly higher in school-aged children 7-14 years, however, the association was non-significant on multivariate logistic regression analysis (OR = 1.8, p = 0.218). 0f 115 successful amplified genes for cox 1 mitochondria DNA, the occurrence of Schistosoma haematobium x Schistosoma bovis hybrids infection was 4 (3.5%) varied significantly among villages (P=.035). Praziquantel yielded a satisfactory cure rate above 90% with no significantly differences among age groups, occupations and sexes (P>0.05). Conclusion: Findings suggest that schistosomiasis is still a public health problem in the study area and S. haematobium x S. bovis hybrid exists. However, the occurrence of S. haematobium x S. bovis hybrid among infected individuals in this study is relatively small which hindered the accurate analysis of praziquantel efficacy against Schistosoma hybrid infection which needs further investigation. Another study with an extended period of assessment and with an increased sample size could improve the evaluation of the efficacy of PZQ on Schistosoma hybrids in the study.
600			_xPublic Health _930696
700			_aSafari Kinung'hi _945138
700			_aMaria Zinga _926705
942			_2ddc _cMP
999			_c18565 _d18565