000			04442nam a22003497a 4500
003			OSt
005			20240305193652.0
008			220202b |||||||| |||| 00| 0 eng d
028			_bPhone: +255 28 298 3384
028			_bFax: +255 28 298 3386
028			_b Email: vc@bugando.ac.tz
028			_bWebsite: www.bugando.ac.tz
040			_cData centre
041			_aEnglish
041			_aKiswahili
100			_aNoel J. Chakwe _dCUHAS/MD/4002139/T/17 _930371
245			_aCandiduria: A Neglected Fungus Infection of UTI Patients at Bugando Medical Centre Mwanza, Tanzania
260			_aMwanza, Tanzania: _bCatholic University of Health and Allied Sciences [CUHAS – Bugando] _c©17.08.2022
300			_axii; 24 Pages
300			_aIncludes References and Appendices
520			_aAbstract: Background: Candiduria is the presence of significant number of Candida species (spp) in the urinary tract system coupled with clinical signs and symptoms. Urinary tract infections (UTIs) as a result of Candida spp. is becoming increasing among diseased individuals with other predisposing conditions like diabetes mellitus or structural abnormalities of the urinary tract systems or in catheterized patients and those in HDU and ICU. Data on the magnitude of Candiduria in the study settings are still limited. Studies done elsewhere have documented the presence of candida in urine whereby the patients were treated as UTI due to other causes and not Candiduria Objectives: Objective of this study was to determine the prevalence of Candiduria among patients with clinical diagnosis of UTI attended at BMC microbiology laboratory Methodologies: This study was conducted at Bugando Medical Centre (BMC), Mwanza, Tanzania. It was a cross-sectional study which utilized lab records from January 2020 to December 2020 that were retrieved from the computer system of BMC. The study included data of patients whose urine was cultured at BMC microbiology laboratory from January 2020 to December 2020. Data were extracted from the EHMS computer system of BMC to excel sheet for cleaning and coding before being transferred to STATA for analysis. Categorical data were summarized using proportions while continuous data were summarized using median and interquartile range. A chi squared test was used to determine factors associated with candiduria. A p value less than 0.05 at 95% CI was considered statistically significant. Results: A data of 14142 patients with clinical diagnosis of UTI for the period of one year was retrieved from hospital information system. Majority of patients were females 9202 (65.07%) and 4940 (34.93) % were males. Their mean age was 26 years with standard deviation (SD) of 2years. Of the participants 7428(52.52) % patients were outpatients and 6714(47.47) % patients were in patients. Based on total collected sample, 2300(16.26%) patients were recorded to have leucocytes in urine and 11842 (83.73%) had no leukocytosis in urine. The growth of greater than 10^5CFU of Candida spp. per milliliter of urine was reported in 77 (0.5%) patients, 17 patients had leukocytosis with yeast growth and 60 patients had yeast growth without leukocytosis. There was no difference in proportions of patients with candiduria among those with or without leukocytosis 17(0.74%, n=2300) vs 60(2.6%, n=11842), p=0.1503. Relative higher proportion of Candiduria was documented among patients with comorbidities like chronic kidney diseases, diabetic mellitus and cancer. Majority of patient with candiduria were not treated with antifungal agents. Conclusion: This study gives a clear picture of the prevalence of Candiduria among UTI patients Candiduria is estimated to affect 3 out of 100 patients who are clinically diagnosed to have UTI. Candida species in urine are pronounced more to patients with diabetes, prolonged catheterization, prolonged admission to HDU and ICU, HIV/AIDS and kidney malignances. Clinicians at tertiary hospitals should consider urinary Candidiasis among patients in risk group who present with UTI like symptoms.
600			_xEpidemiology _930372
600			_xMolecular Biology
600			_xNeurology _931547
600			_xBiochemistry _915676
600			_xMicrobiology and Immunology _948529
700			_aEveline Konje _922961
700			_a Martha Mushi _919642
700			_aSarah Matuja _926688
700			_aFelix Tarimo _926662
942			_2ddc _cMP
999			_c18523 _d18523